HC5B9-140K

MILLIPLEX^® Human Complement C5b-9 - Singleplex

• Synonyme(s) : Human complement multiplex kit, Luminex human complement immunoassay, Millipore human complement panel, Human membrane attack complex,, human MAC panel, Luminex human complement panel, terminal complement complex, MAC, membrane attack complex
• Code UNSPSC : 12161503
• Nomenclature NACRES : NA.84

Propriétés

• Espèces réactives: human
• Niveau de qualité: 200
• Paramètres: 25 μL sample volume (per well diluted sample)
• assay range: recovery range: 100%; (same day assay); recovery range: 120%; (overnight assay); inter-assay cv: ≤15%; intra-assay cv: ≤15%; standard curve range: 0.6-450 ng/mL
• Technique(s): multiplexing: suitable
• Méthode de détection: fluorometric (Luminex^® xMAP^®)
• Conditions d'expédition: wet ice
• Température de stockage: 2-8°C

Description

Description générale

The complement system consists of many plasma proteins that assist, or complement, the ability of phagocytic cells and antibodies to clear pathogens. Although it is part of the innate immune system, it can be recruited and activated by the adaptive immune system. The complement proteins and glycoproteins that are synthesized primarily by hepatocytes normally circulate as inactive pro-proteins. Once stimulated the result of the cascade is a massive amplification of response and activation of the membrane attack complex (C5b-9), which forms a transmembrane pore causing osmotic lysis of target cells. The complement pathway may also form soluble C5b-9, as well as intermediate isoforms, stabilized by regulatory proteins. These soluble complexes are unable to insert into the lipid membrane, and their role in complement pathways is an area of ongoing research.

Research category : Inflammation & Immunology
Research sub-category : Inflammation & Autoimmune Mechanisms; Inflammation

Spécificité

Cross-Reactivity between C5b-9 and other complement proteins found in MILLIPLEX^® Human Complement Expanded panel 1 (Cat. No. HCMPEX1-19K) and MILLIPLEX^® Human Complement Panel 2 (Cat. No. HCMP2MAG-19K) was tested. There was no or negligible cross-reactivity between the antibody pair in this panel for any of the analytes tested.

Application

MILLIPLEX^® Human Complement C5b-9 – Singleplex Magnetic Bead Panel is a Singleplex kit to be used for the quantification of the following analyte in serum, plasma, or cell culture supernatant samples: C5b-9 (Membrane Attack Complex, Terminal Complement Complex).

Caractéristiques et avantages

Everything you need in a single kit

Informations légales

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS05,GHS07,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H302 + H312 + H332,H317,H318,H373,H411
• Conseils de prudence: P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P314
• Classification des risques: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
• Organes cibles: Respiratory Tract
• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3