ABN73
Anti-Neutral amino acid transporter (ASCT2) Antibody
from rabbit, purified by affinity chromatography
Synonyme(s) :
Neutral amino acid transporter B(0), Baboon M7 virus receptor, RD114/simian type D retrovirus receptor, Sodium-dependent neutral amino acid transporter type 2, Solute carrier family 1 member 5
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Produit purifié par
affinity chromatography
Espèces réactives
human
Technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... SLC1A5(6510)
Description générale
Neutral amino acid transporter, also known as ASCT2, is an alternate of the ASC (alanine-, serine-, cysteine-) transport system and is highly expressed in rat astroglia-rich cultures while not highly expressed in rat neuron-rich cultures. ASCT2 is also thought to be important in the glutamine release from cells. ASCT2 has been implicated in the growth and survival of cancer cells, therefore making it a possible target for cancer therapy. ASCT2 is thought to be a crucial neuronal neutral amino acid transporter.
Spécificité
No homology found to mouse or rat. Other homologies: rhesus monkey (93% sequence homology).
This antibody recognizes Neutral amino acid transporter at the N-terminus.
Immunogène
Epitope: N-terminus
KLH-conjugated linear peptide corresponding to the N-terminus of Neutral amino acid transporter.
Application
Anti-Neutral amino acid transporter (ASCT2) Antibody detects level of Neutral amino acid transporter (ASCT2) & has been published & validated for use in WB, IH(P).
Immunohistochemistry Analysis: 1:1000 dilution from a previous lot detected Neutral amino acid transporter in human prostate tissue.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Ion Channels & Transporters
Ion Channels & Transporters
Qualité
Evaluated by Western Blot in human placenta tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Neutral amino acid transporter on 10 µg of human placenta tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Neutral amino acid transporter on 10 µg of human placenta tissue lysate.
Description de la cible
~ 57 kDa observed
Forme physique
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Stockage et stabilité
Stable for 1 year at 2-8°C from date of receipt.
Remarque sur l'analyse
Control
Human placenta tissue lysate
Human placenta tissue lysate
Autres remarques
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Niki M Zacharias et al.
International journal of molecular sciences, 22(6) (2021-04-04)
Von Hippel Lindau (VHL) inactivation, which is common in clear cell renal cell carcinoma (ccRCC), leads directly to the disruption of oxygen homoeostasis. VHL works through hypoxia-inducible factors (HIFs). Within this VHL-HIF system, prolyl hydroxylases (PHDs) are the intermediary proteins
Patrik da Silva Vital et al.
International journal of molecular sciences, 23(24) (2022-12-24)
(1) BRAF mutations are associated with high mortality and are a substantial factor in therapeutic decisions. Therapies targeting BRAF-mutated tumors, such as vemurafenib (PLX), have significantly improved the overall survival of melanoma patients. However, patient relapse and low response rates
Michael L Schulte et al.
Nature medicine, 24(2), 194-202 (2018-01-16)
The unique metabolic demands of cancer cells underscore potentially fruitful opportunities for drug discovery in the era of precision medicine. However, therapeutic targeting of cancer metabolism has led to surprisingly few new drugs to date. The neutral amino acid glutamine
Da Hee Jung et al.
Life (Basel, Switzerland), 10(10) (2020-10-18)
Electroacupuncture (EA) therapy via alternating current stimulation on the scalp over the motor cortex is used for the treatment of brain disorders. Perinatal hypoxia-ischemia (HI), a brain injury in newborns, leads to long-term neurologic complications. Here, we investigated whether EA
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