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Key Documents

857370P

Avanti

VU0155056

Avanti Research™ - A Croda Brand 857370P, powder

Synonyme(s) :

N-(2-{4-[2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl}ethyl)-2-naphthamide

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About This Item

Formule empirique (notation de Hill):
C25H26N4O2
Numéro CAS:
1130067-18-3
Poids moléculaire :
414.50
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Pureté

>99% (TLC)

Forme

powder

Conditionnement

pkg of 1 × 1 mg (857370P-1mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 857370P

Type de lipide

bioactive lipids

Conditions d'expédition

dry ice

Température de stockage

−20°C

Application

VU0155056 has been used as a phospholipase D-1 (PLD1) inhibitor:
  • to study its role in regulated exocytosis
  • to test bacterial and human PLD enzymes for specificity of inhibition
  • in neuro-2a (N2a) cell culture and survival assay

Actions biochimiques/physiologiques

VU0155056 or N-(2-{4-[2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl ethyl)-2-naphthamide is a cell permeable phospholipase D (PLD) inhibitor. It inhibits both PLD1 and PLD2.

Conditionnement

5 mL Amber Glass Screw Cap Vial (857370P-1mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Aditya Kulkarni et al.
Chemical biology & drug design, 84(3), 270-281 (2014-03-20)
Phospholipase D enzymes cleave lipid substrates to produce phosphatidic acid, an important precursor for many essential cellular molecules. Phospholipase D is a target to modulate cancer-cell invasiveness. This study reports synthesis of a new class of phospholipase D inhibitors based
Sarah McDavid et al.
PloS one, 9(10), e109203-e109203 (2014-10-03)
Butanol (C4H10OH) has been used both to dissect the molecular targets of alcohols/general anesthetics and to implicate phospholipase D (PLD) signaling in a variety of cellular functions including neurotransmitter and hormone exocytosis. Like other primary alcohols, 1-butanol is a substrate
Michael A Kennedy et al.
PLoS genetics, 7(2), e1001299-e1001299 (2011-02-25)
During Alzheimer's Disease, sustained exposure to amyloid-β₄₂ oligomers perturbs metabolism of ether-linked glycerophospholipids defined by a saturated 16 carbon chain at the sn-1 position. The intraneuronal accumulation of 1-O-hexadecyl-2-acetyl-sn-glycerophosphocholine (C16:0 PAF), but not its immediate precursor 1-O-hexadecyl-sn-glycerophosphocholine (C16:0 lyso-PAF), participates
Sarah A Scott et al.
Nature chemical biology, 5(2), 108-117 (2009-01-13)
Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid. Phosphatidic acid participates in both G protein-coupled receptor and receptor tyrosine kinase signal transduction networks. The lack of potent and isoform-selective inhibitors
Tatiana P Rogasevskaia et al.
The Journal of biological chemistry, 290(48), 28683-28696 (2015-10-04)
There are a diversity of interpretations concerning the possible roles of phospholipase D and its biologically active product phosphatidic acid in the late, Ca(2+)-triggered steps of regulated exocytosis. To quantitatively address functional and molecular aspects of the involvement of phospholipase

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