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39391

Sigma-Aldrich

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide

≥97.0% (T), for peptide synthesis

Synonyme(s) :

N-Ethyl-N′-(3-dimethylaminopropyl)carbodiimide, EDC, WSC

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About This Item

Formule empirique (notation de Hill):
C8H17N3
Numéro CAS:
1892-57-5
Poids moléculaire :
155.24
Numéro Beilstein :
507429
Numéro CE :
217-579-2
Numéro MDL:
MFCD00044916
Code UNSPSC :
12352116
ID de substance PubChem :
57649895
Nomenclature NACRES :
NA.22

product name

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide, ≥97.0% (T)

Pureté

≥97.0% (T)

Forme

liquid

Capacité de réaction

reaction type: Coupling Reactions

Indice de réfraction

n20/D 1.461

Densité

0.877 g/mL at 20 °C (lit.)

Application(s)

peptide synthesis

Température de stockage

−20°C

Chaîne SMILES 

CCN=C=NCCCN(C)C

InChI

1S/C8H17N3/c1-4-9-8-10-6-5-7-11(2)3/h4-7H2,1-3H3

Clé InChI

LMDZBCPBFSXMTL-UHFFFAOYSA-N

Description générale

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide is commonly used in combination with N-hydroxysuccinimide (NHS) in carbodiimide coupling reaction to activate carboxyl group for coupling with amines to form amides.

Application

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide has been used for the surface functionalization of graphene quantum dots (GQDs) employed as sensing probes in Janus micromotors to detect enterobacterial contamination. It has also been used for the activation of folic acid, prior to its conjugation on silica nanoparticles.

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A - Skin Sens. 1A - STOT RE 2 Oral

Organes cibles

Stomach,large intestine,lymph node

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

J David Stack et al.
Journal of tissue engineering and regenerative medicine, 11(10), 2785-2795 (2016-05-21)
Osteochondral lesions resulting from osteochondritis dissecans are problematic to treat and present a significant challenge for clinicians. The aims of this study were to investigate the use of a scaffold-assisted microfracture approach, employing a novel, multilayered, collagen-based, osteochondral graft substitute
Anthony C Y Yau et al.
Scientific reports, 7(1), 14998-14998 (2017-11-10)
Mineral oils are extensively used in our daily life, in food, cosmetics, biomedicine, vaccines and in different industrial applications. However, exposure to these mineral oils has been associated with immune adjuvant effects and the development of autoimmune diseases. Here we
Folic acid-conjugated organically modified silica nanoparticles for enhanced targeted delivery in cancer cells and tumor in vivo.
Yin F
Journal of Material Chemistry B: Materials for Biology and Medicine, 3(29), 6081-6093 (2015)
Yumei Wang et al.
Materials science & engineering. C, Materials for biological applications, 103, 109737-109737 (2019-07-28)
In this study, twisted rod-like chiral mesoporous silicas (CMSs) with discriminating chiral characteristics (D/L) were designed and biomimetic synthesized by using L- and d-alanine derivatives as templates, and employed as poorly water-soluble chiral drug ibuprofen (IBU) carriers. The morphology and
Ruogu Qi et al.
Nature communications, 8(1), 2166-2166 (2017-12-20)
Advanced-stage epithelial ovarian cancers are amongst the most difficult to treat tumors and have proven to be refractory to most cytotoxic, molecularly targeted, or immunotherapeutic approaches. Here, we report that nanoparticle-drug conjugates (NDCs) of monomethyl auristatin E (MMAE) significantly increase
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