A7252

Ajmaline

• Formule empirique (notation de Hill) : C₂₀H₂₆N₂O₂
• Numéro CAS: 4360-12-7
• Poids moléculaire : 326.43
• UNSPSC Code: 41116107
• EC Number: 224-439-4
• MDL number: MFCD00135652

Propriétés

• storage temp.: 2-8°C
• SMILES string: CCC1C(O)N2C3CC1C4C(O)C5(CC24)[C@H]3N(C)c6ccccc56

Description

Biochem/physiol Actions

Indole alkaloid from Rauwolfia serpentina that is a Class Ia antiarrhythmia compound. It blocks sodium channels in skeletal and cardiac muscle and cardiac HERG potassium channels in the open state but not in the closed state. Ajmaline administered intravenously prolongs the atrioventricular (AV) conduction times in the heart and has been used diagnostically to detect AV block and other cardiac abnormalities.

Informations sur la sécurité

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves