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Merck

PTPN1

protein tyrosine phosphatase, non-receptor type 1

Synonymes:
PTP1B
Espèce(s):
Human PTPN1 (5770), Mouse Ptpn1 (19246), Rat Ptpn1 (24697), chicken PTPN1 (395688), Zebrafish ptpn1 (30081), cow PTPN1 (508658), Domestic Rabbit PTPN1 (100354834), Horse PTPN1 (100052066), domestic cat PTPN1 (101099626), dog PTPN1 (477263) ...Plus
ID UniProtKB:
P18031, Q5TGD8, Q9BQV9, Q9NQQ4
ID du gène:
  • Human(5770) Summary: The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
  • Mouse(19246) protein tyrosine phosphatase, non-receptor type 1
  • Rat(24697) protein tyrosine phosphatase, non-receptor type 1
  • chicken(395688) protein tyrosine phosphatase, non-receptor type 1
  • Zebrafish(30081) protein tyrosine phosphatase, non-receptor type 1
  • cow(508658) protein tyrosine phosphatase, non-receptor type 1
  • Domestic Rabbit(100354834) protein tyrosine phosphatase, non-receptor type 1
  • Horse(100052066) protein tyrosine phosphatase, non-receptor type 1
  • domestic cat(101099626) protein tyrosine phosphatase, non-receptor type 1
  • dog(477263) protein tyrosine phosphatase, non-receptor type 1
  • naked mole-rat(101696680) protein tyrosine phosphatase, non-receptor type 1
  • domestic guinea pig(100730699) protein tyrosine phosphatase, non-receptor type 1
  • sheep(101118209) protein tyrosine phosphatase, non-receptor type 1

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ELISA

Référence du produit
Description
Espèce(s)
RAB1657
Human PTP1B ELISA, for serum, plasma and cell culture supernatants,
Espèce(s)
human

Antibodies

Référence du produit
Description
Espèces réactives
Application
MABS456
Anti-PTP1B Antibody (Oxidized), clone scFvs 45, clone scFvs 45, from chicken,
Espèces réactives
human
Application
immunoprecipitation (IP)
MABS197
Anticorps anti-PTP1B, clone FG6-1G, clone FG6-1G, from mouse,
Espèces réactives
human
Application
immunoprecipitation (IP)
western blot
HPA012542
Anti-PTPN1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
western blot
SAB4301535
Anti-phospho-PTP1B (pSer50) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, monkey, mouse, rat
Application
western blot
SAB4502525
Anti-PTP1B antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
A79604
4-Aminosalicylic acid, 99%,
Espèce(s)
human
C85603
Coumarin-3-carboxylic acid, 99%,
Espèce(s)
human
301353
2,6-Naphthalenedicarboxylic acid, 95%,
Espèce(s)
human
523763
2,6-Naphthalenedicarboxylic acid, 99%,
Espèce(s)
human
383449
3-Formylchromone, 97%,
Espèce(s)
human

Kits

Référence du produit
Description
Espèce(s)
17-125
Kit d'analyse de la PTP n°1, PTP Assay Kit 1 can be used to detect PTP-1B activity by dephosphorylation of the phosphopeptide (RRLIEDAEpYAARG) using malachite green detection, or by hydrolysis of pNPP.,
Espèce(s)
human

Proteins

Référence du produit
Description
Espèce(s)
SRP0212
PTP1B (1-321)/PTPN1 Active human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE),
Espèce(s)
human
P6244
Protein Tyrosine Phosphatase 1B human, recombinant, expressed in E. coli,
Espèce(s)
human
SRP0215
PTP1B full length Active human, recombinant, expressed in E. coli, aqueous solution, ≥55% (SDS-PAGE),
Espèce(s)
human
SRP0213
PTP1B (1-321)/PTPN1 Active from mouse, recombinant, expressed in E. coli, ≥90% (SDS-PAGE),
Espèce(s)
human
SRP5071
PTPN1, active, GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
EHU016451
MISSION® esiRNA, targeting human PTPN1,
Espèce(s)
human
EMU061791
MISSION® esiRNA, targeting mouse Ptpn1,
Espèce(s)
mouse