PML
promyelocytic leukemia
Synonymes:
MYL, PP8675, RNF71, TRIM19
Espèce(s):
Human PML (5371), Mouse Pml (18854), Rat Pml (315713), chicken PML (415302), chicken PML (415304), domestic cat PML (101086975), dog PML (487641), sheep PML (101111580), cow PML (100138545), Horse PML (100062744) ...Plus
ID UniProtKB:
ID du gène:
- Human(5371) Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- Mouse(18854) promyelocytic leukemia
- Rat(315713) promyelocytic leukemia
- chicken(415302) promyelocytic leukemia
- chicken(415304) promyelocytic leukemia
- domestic cat(101086975) promyelocytic leukemia
- dog(487641) promyelocytic leukemia
- sheep(101111580) promyelocytic leukemia
- cow(100138545) promyelocytic leukemia
- Horse(100062744) promyelocytic leukemia
- naked mole-rat(101707749) promyelocytic leukemia
- domestic guinea pig(100720832) promyelocytic leukemia
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anticorps anti-PML, clone 36,1-104, clone 36.1-104, Upstate®, from mouse,
Espèces réactives
mouse
Application
immunocytochemistry
western blot
western blot
Anti-PML antibody, Mouse monoclonal, clone PML-97, purified from hybridoma cell culture,
Espèces réactives
hamster, human, mouse
Application
ELISA
immunocytochemistry
immunoprecipitation (IP)
microarray
western blot
immunocytochemistry
immunoprecipitation (IP)
microarray
western blot
Rabbit anti-PML Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Espèces réactives
human
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-PML Isoform II Antibody, clone 1A8.1, clone 1A8.1, from mouse,
Espèces réactives
human
Application
immunocytochemistry
western blot
western blot
Anti-PML antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry