Accéder au contenu
Merck

NR3C2

nuclear receptor subfamily 3, group C, member 2

Synonymes:
MCR, MLR, MR, NR3C2VIT
Espèce(s):
Human NR3C2 (4306), Mouse Nr3c2 (110784), Rat Nr3c2 (25672), sheep NR3C2 (101107046), cow NR3C2 (280861), cow NR3C2 (537614), domestic cat NR3C2 (101081977), Horse NR3C2 (100062570), dog NR3C2 (475461), chicken NR3C2 (374131) ...Plus
ID UniProtKB:
P08235, B0ZBF5, Q2NKL1, Q96KQ8, Q96KQ9
ID du gène:
  • Human(4306) Summary: This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
  • Mouse(110784) nuclear receptor subfamily 3, group C, member 2
  • Rat(25672) nuclear receptor subfamily 3, group C, member 2
  • sheep(101107046) nuclear receptor subfamily 3, group C, member 2
  • cow(280861) nuclear receptor subfamily 3, group C, member 2
  • cow(537614) nuclear receptor subfamily 3, group C, member 2
  • domestic cat(101081977) nuclear receptor subfamily 3, group C, member 2
  • Horse(100062570) nuclear receptor subfamily 3, group C, member 2
  • dog(475461) nuclear receptor subfamily 3, group C, member 2
  • chicken(374131) nuclear receptor subfamily 3, group C, member 2
  • domestic guinea pig(100735309) nuclear receptor subfamily 3, group C, member 2
  • Zebrafish(562171) nuclear receptor subfamily 3, group C, member 2

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Small Molecule - Agonist

Référence du produit
Description
Espèce(s)
D7000
Deoxycorticosterone acetate, ,
Espèce(s)
human
F6127
Fludrocortisone acetate, ≥98%,
Espèce(s)
human
1273003
Fludrocortisone acetate, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
1174001
Deoxycorticosterone acetate, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
F0180000
Fludrocortisone acetate, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human

Small Molecule - Antagonist

Référence du produit
Description
Espèce(s)
E6657
Eplerenone, ≥98% (HPLC),
Espèce(s)
human
SML1497
Canrenone, ≥97% (HPLC),
Espèce(s)
human
1619017
Spironolactone Related Compound A, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
1619006
Spironolactone, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
1237553
Eplerenone, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human

Antibodies

Référence du produit
Description
Espèces réactives
Application
MABS1250
Anti-Mineralocorticoid Receptor Antibody, clone 2D6, clone 2D6, from mouse,
Espèces réactives
rat
Application
immunocytochemistry
immunohistochemistry
western blot
AV45599
Anti-NR3C2 antibody produced in rabbit, IgG fraction of antiserum,
Espèces réactives
human, rabbit
Application
immunohistochemistry
western blot
HPA074979
Anti-NR3C2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
SAB2104689
Anti-NR3C2, (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
horse, human
Application
western blot

esiRNA

Référence du produit
Description
Espèce(s)
EHU088591
MISSION® esiRNA, targeting human NR3C2,
Espèce(s)
human
EMU201261
MISSION® esiRNA, targeting mouse Nr3c2,
Espèce(s)
mouse