NCOA2
nuclear receptor coactivator 2
Synonymes:
GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75
Espèce(s):
Human NCOA2 (10499), Mouse Ncoa2 (17978), Rat Ncoa2 (83724), domestic cat NCOA2 (101094648), naked mole-rat Ncoa2 (101700727), cow NCOA2 (508162), dog NCOA2 (486989), Horse NCOA2 (100051656), Zebrafish ncoa2 (81884), chicken NCOA2 (420176) ...Plus
ID UniProtKB:
ID du gène:
- Human(10499) Summary: The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]
- Mouse(17978) nuclear receptor coactivator 2
- Rat(83724) nuclear receptor coactivator 2
- domestic cat(101094648) nuclear receptor coactivator 2
- naked mole-rat(101700727) nuclear receptor coactivator 2
- cow(508162) nuclear receptor coactivator 2
- dog(486989) nuclear receptor coactivator 2
- Horse(100051656) nuclear receptor coactivator 2
- Zebrafish(81884) nuclear receptor coactivator 2
- chicken(420176) nuclear receptor coactivator 2
- domestic guinea pig(100735429) nuclear receptor coactivator 2
- sheep(101104249) nuclear receptor coactivator 2
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-NCOA2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
Anti-NCOA2 antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-NCoA-2 Antibody, clone 3Ti-3C11, ,
Espèces réactives
feline, horse, human, mouse
Application
ChIP
ELISA
western blot
ELISA
western blot
esiRNA
Référence du produit
Description
Espèce(s)