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Merck

KCNJ1

potassium inwardly-rectifying channel, subfamily J, member 1

Synonymes:
KIR1.1, ROMK, ROMK1
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(3758) Summary: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(56379) potassium inwardly-rectifying channel, subfamily J, member 1
  • Rat(24521) potassium inwardly-rectifying channel, subfamily J, member 1
  • chicken(428236) potassium inwardly-rectifying channel, subfamily J, member 1
  • Horse(100072580) potassium inwardly-rectifying channel, subfamily J, member 1
  • domestic cat(101091140) potassium inwardly-rectifying channel, subfamily J, member 1
  • cow(539250) potassium inwardly-rectifying channel, subfamily J, member 1
  • dog(489285) potassium inwardly-rectifying channel, subfamily J, member 1
  • naked mole-rat(101720253) potassium inwardly-rectifying channel, subfamily J, member 1
  • domestic guinea pig(100722828) potassium inwardly-rectifying channel, subfamily J, member 1

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Small Molecule - Activator

Référence du produit
Description
Espèce(s)
Diazoxide, ,
Espèce(s)
rat, mouse, human

Small Molecule - Antagonist

Référence du produit
Description
Espèce(s)
Cromakalim, ,
Espèce(s)
rat
Glyburide, meets USP testing specifications,
Espèce(s)
rat, human
Glybenclamide, ≥99% (HPLC),
Espèce(s)
rat, human
Chlorpropamide, analytical standard, ≥97%,
Espèce(s)
human, mouse
Tolbutamide, analytical standard,
Espèce(s)
human, mouse

Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-KCNJ1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Anti-KCNJ1 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
dog, guinea pig, horse, human, rabbit, rat
Application
western blot
Anti-ROMK antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence
Anti-KCNJ1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
human, mouse, rat
Application
ELISA
western blot

Small Molecule - Blocker

Référence du produit
Description
Espèce(s)
Gliclazide, powder, ≥98%,
Espèce(s)
human
Glimepiride, ≥98% (HPLC), solid,
Espèce(s)
human
Repaglinide, ≥98% (HPLC), solid,
Espèce(s)
human
Glipizide, solid,
Espèce(s)
human
Glyburide, meets USP testing specifications,
Espèce(s)
rat, human

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
Linopirdine, ≥98% (HPLC),
Espèce(s)
rat
VU591, ≥98% (HPLC),
Espèce(s)
human
Tertiapin-Q trifluoroacetate salt, ≥97% (HPLC),
Espèce(s)
rat, human, mouse
Chlorpropamide, analytical standard, ≥97%,
Espèce(s)
human, mouse
Tolbutamide, analytical standard,
Espèce(s)
human, mouse

Small Molecule - Ligand

Référence du produit
Description
Espèce(s)
Glimepiride, ≥98% (HPLC), solid,
Espèce(s)
human
Glipizide, solid,
Espèce(s)
human
Glybenclamide, ≥99% (HPLC),
Espèce(s)
rat, human
Chlorpropamide, analytical standard, ≥97%,
Espèce(s)
human, mouse

Small Molecule - Opener

Référence du produit
Description
Espèce(s)
Minoxidil, ≥99% (TLC),
Espèce(s)
human
Diazoxide, ,
Espèce(s)
rat, mouse, human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human KCNJ1,
Espèce(s)
human