IMPA1
inositol(myo)-1(or 4)-monophosphatase 1
Synonymes:
IMP, IMPA
Espèce(s):
Human IMPA1 (3612), Mouse Impa1 (55980), Rat Impa1 (83523), domestic guinea pig Impa1 (100723610), naked mole-rat Impa1 (101704416), domestic cat IMPA1 (101088214), cow IMPA1 (281865), sheep IMPA1 (101119912), chicken IMPA1 (420199), dog IMPA1 (477925)
ID UniProtKB:
ID du gène:
- Human(3612) Summary: This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Nov 2009]
- Mouse(55980) inositol (myo)-1(or 4)-monophosphatase 1
- Rat(83523) Inositol (myo)-1(or 4)-monophosphatase 1
- domestic guinea pig(100723610) inositol(myo)-1(or 4)-monophosphatase 1
- naked mole-rat(101704416) inositol(myo)-1(or 4)-monophosphatase 1
- domestic cat(101088214) inositol(myo)-1(or 4)-monophosphatase 1
- cow(281865) inositol(myo)-1(or 4)-monophosphatase 1
- sheep(101119912) inositol(myo)-1(or 4)-monophosphatase 1
- chicken(420199) inositol(myo)-1(or 4)-monophosphatase 1
- dog(477925) inositol(myo)-1(or 4)-monophosphatase 1
- Zebrafish(437018) inositol(myo)-1(or 4)-monophosphatase 1
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Monoclonal Anti-IMPA1 antibody produced in mouse, clone 1E6-F11, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
western blot
western blot
Monoclonal Anti-IMPA1 antibody produced in mouse, clone 1E6-F11, ascites fluid,
Espèces réactives
human
Application
ELISA
western blot
western blot
Anti-IMPA1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-IMPA1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human, mouse
Application
immunofluorescence
western blot
western blot
Small Molecule - Inhibitor
Référence du produit
Description
Espèce(s)
Lithium carbonate, puriss. p.a., ACS reagent, reagent (for microscopy), ≥99.0% (T),
Espèce(s)
human