GRN
granulin
Synonymes:
CLN11, GEP, GP88, PCDGF, PEPI, PGRN
Espèce(s):
Human GRN (2896), Mouse Grn (14824), Rat Grn (29143), fruit fly grn (40962), dog GRN (480501), Horse GRN (100051035), domestic cat GRN (101100680), cow GRN (767942), sheep GRN (101115470), Domestic Rabbit GRN (100349528) ...Plus
ID UniProtKB:
ID du gène:
- Human(2896) Summary: Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
- Mouse(14824) granulin
- Rat(29143) granulin
- fruit fly(40962) grain
- dog(480501) granulin
- Horse(100051035) granulin
- domestic cat(101100680) granulin
- cow(767942) granulin
- sheep(101115470) granulin
- Domestic Rabbit(100349528) granulin
- domestic guinea pig(100135533) granulin
- naked mole-rat(101715753) granulin
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ELISA
Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-GRN antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-GRN antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
western blot
western blot
Anti-Granulin (C-terminal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
western blot
western blot
Anti-Progranulin/GRN Antibody, clone 8H10, clone 8H10, from rat,
Espèces réactives
mouse
Application
immunohistochemistry
western blot
western blot
Anti-GRN antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Proteins
Référence du produit
Description
Espèce(s)
Progranulin human, recombinant, expressed in HEK 293 cells, untagged, >95% (SDS-PAGE),
Espèce(s)
human
Progranulin mouse, recombinant, expressed in HEK 293 cells, untagged, >95% (SDS-PAGE),
Espèce(s)
mouse
Granulin C human, recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE),
Espèce(s)
human
Progranulin mouse, recombinant, expressed in HEK 293 cells, FLAG® tagged, >95% (SDS-PAGE),
Espèce(s)
mouse
Progranulin rat, recombinant, expressed in HEK 293 cells, FLAG® tagged, >95% (SDS-PAGE),
Espèce(s)
rat