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Merck

GABRD

gamma-aminobutyric acid (GABA) A receptor, delta

Synonymes:
EIG10, EJM7, GEFSP5
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(2563) Summary: Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This gene encodes the delta subunit. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures, type 5. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
  • Mouse(14403) gamma-aminobutyric acid (GABA) A receptor, subunit delta
  • Rat(29689) gamma-aminobutyric acid (GABA) A receptor, delta
  • Zebrafish(571422) gamma-aminobutyric acid (GABA) A receptor, delta
  • chicken(770710) gamma-aminobutyric acid (GABA) A receptor, delta
  • cow(508711) gamma-aminobutyric acid (GABA) A receptor, delta
  • dog(489609) gamma-aminobutyric acid (GABA) A receptor, delta
  • sheep(101122539) gamma-aminobutyric acid (GABA) A receptor, delta
  • domestic cat(101087589) gamma-aminobutyric acid (GABA) A receptor, delta
  • domestic guinea pig(100735228) gamma-aminobutyric acid (GABA) A receptor, delta
  • naked mole-rat(101700143) gamma-aminobutyric acid (GABA) A receptor, delta

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Small Molecule - Agonist

Référence du produit
Description
Espèce(s)
Meprobamate solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
Oxazepam, ,
Espèce(s)
human
Meprobamate, analytical standard,
Espèce(s)
human
2-Bromo-2-chloro-1,1,1-trifluoroethane, ≥99%,
Espèce(s)
human

Small Molecule - Allosteric Modulator

Référence du produit
Description
Espèce(s)
Midazolam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
Diazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
Oxazepam solution, 1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
Alprazolam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
Etomidate, >98% (HPLC), powder,
Espèce(s)
human

Small Molecule - Antagonist

Référence du produit
Description
Espèce(s)
Flumazenil, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Flunitrazepam, ,
Espèce(s)
human
Clonazepam, powder,
Espèce(s)
human, rat
Ganaxolone, ≥98% (HPLC), solid,
Espèce(s)
human, mouse
Diazepam, ,
Espèce(s)
human, rat

Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-GABRD antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Anti-GABRD antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
bovine, dog, human, mouse, rabbit
Application
immunohistochemistry
western blot

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human GABRD,
Espèce(s)
human
MISSION® esiRNA, targeting mouse Gabrd,
Espèce(s)
mouse