DUSP1
dual specificity phosphatase 1
Synonymes:
CL100, HVH1, MKP-1, MKP1, PTPN10
Espèce(s):
Human DUSP1 (1843), Mouse Dusp1 (19252), Rat Dusp1 (114856), Domestic Rabbit DUSP1 (100340993), sheep DUSP1 (101107632), naked mole-rat Dusp1 (101701425), domestic guinea pig Dusp1 (100725668), chicken DUSP1 (374192), Zebrafish dusp1 (406340), dog DUSP1 (489117) ...Plus
ID UniProtKB:
ID du gène:
- Human(1843) Summary: The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008]
- Mouse(19252) dual specificity phosphatase 1
- Rat(114856) dual specificity phosphatase 1
- Domestic Rabbit(100340993) dual specificity phosphatase 1
- sheep(101107632) dual specificity phosphatase 1
- naked mole-rat(101701425) dual specificity phosphatase 1
- domestic guinea pig(100725668) dual specificity phosphatase 1
- chicken(374192) dual specificity phosphatase 1
- Zebrafish(406340) dual specificity phosphatase 1
- dog(489117) dual specificity phosphatase 1
- cow(539175) dual specificity phosphatase 1
- domestic cat(101093416) dual specificity phosphatase 1
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Numéro du produit
Description
Espèces réactives
Application
Anti Dual specificity phosphatase 1 Antibody, clone 23GB5760, Rabbit Monoclonal, clone 23GB5760, recombinant rabbit monoclonal, expressed in HEK293 cells,
Espèces réactives
human, rat
Application
flow cytometry
western blot
western blot
Anti-DUSP1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
western blot
western blot
Anti-MKP1 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-MKP-1/2 (pSer296/318) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
western blot