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Merck

DUOX1

dual oxidase 1

Synonymes:
LNOX1, NOXEF1, THOX1
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(53905) Summary: The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]
  • Mouse(99439) dual oxidase 1
  • Rat(266807) dual oxidase 1
  • sheep(101111972) dual oxidase 1
  • domestic guinea pig(100713662) dual oxidase 1
  • naked mole-rat(101698133) dual oxidase 1
  • Domestic Rabbit(100344845) dual oxidase 1
  • cow(510409) dual oxidase 1
  • dog(403720) dual oxidase 1
  • domestic cat(101091374) dual oxidase 1

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Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-DUOX1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human DUOX1,
Espèce(s)
human
MISSION® esiRNA, targeting mouse Duox1,
Espèce(s)
mouse