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Merck

DIABLO

diablo, IAP-binding mitochondrial protein

Synonymes:
DFNA64, SMAC
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(56616) Summary: This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
  • Mouse(66593) diablo homolog (Drosophila)
  • Rat(288753) diablo, IAP-binding mitochondrial protein
  • chicken(416860) diablo, IAP-binding mitochondrial protein
  • cow(493999) diablo, IAP-binding mitochondrial protein
  • domestic guinea pig(100724526) diablo, IAP-binding mitochondrial protein
  • naked mole-rat(101708166) diablo, IAP-binding mitochondrial protein
  • sheep(101121971) diablo, IAP-binding mitochondrial protein
  • dog(477463) diablo, IAP-binding mitochondrial protein

Custom & Knockdown Gene Products

ELISA

Numéro du produit
Description
Espèce(s)
Mouse Diablo / Diablo Homolog, Mitochondrial ELISA Kit, ,
Espèce(s)
mouse
Rat DIABLO / Diablo Homolog (Drosophila) ELISA Kit, ,
Espèce(s)
rat

Antibodies

Numéro du produit
Description
Espèces réactives
Application
Anti-SMAC antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-Smac/Diablo antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-Smac/DIABLO Antibody, clone 2B9 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
human
Application
flow cytometry
immunocytochemistry

western blot
Anti-DIABLO antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
Anti-Smac antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
human, mouse, rat
Application
ELISA
immunohistochemistry

immunoprecipitation (IP)

western blot

esiRNA

Numéro du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human DIABLO, RP11-512M8.5,
Espèce(s)
human
MISSION® esiRNA, targeting mouse Diablo,
Espèce(s)
mouse