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Merck

CYP11B2

cytochrome P450, family 11, subfamily B, polypeptide 2

Synonymes:
ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P-450C18, P450C18, P450aldo
Espèce(s):
Human CYP11B2 (1585), Mouse Cyp11b2 (13072), Rat Cyp11b2 (24294), domestic guinea pig Cyp11b2 (100379213), Domestic Rabbit CYP11B2 (100328543), cow CYP11B2 (282423), dog CYP11B2 (482071)
ID UniProtKB:
P19099, B0ZBE4, Q16726
ID du gène:
  • Human(1585) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008]
  • Mouse(13072) cytochrome P450, family 11, subfamily b, polypeptide 2
  • Rat(24294) cytochrome P450, family 11, subfamily b, polypeptide 2
  • domestic guinea pig(100379213) aldosterone synthase
  • Domestic Rabbit(100328543) cytochrome P450, family 11, subfamily B, polypeptide 2
  • cow(282423) cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2
  • dog(482071) cytochrome P450, family 11, subfamily B, polypeptide 2

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Antibodies

Numéro du produit
Description
Espèces réactives
Application
MABS1251
Anticorps anti-CYP11B2, clone 41-17B, clone 41-17B, from mouse,
Espèces réactives
human, mouse
Application
immunofluorescence
immunohistochemistry
western blot
HPA049171
Anti-CYP11B2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
HPA057752
Anti-CYP11B2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
HPA049565
Anti-Cyp11B2 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
MAB6021
Anti-Cytochrome P450 Aldosterone Synthase Antibody, clone 1G5, culture supernatant, clone 1G5, Chemicon®,
Espèces réactives
mouse, rat
Application
ELISA
immunocytochemistry
immunohistochemistry
western blot

Small Molecule - Inhibitor

Numéro du produit
Description
Espèce(s)
K1003
Ketoconazole, 99.0-101.0% (EP, titration), meets EP testing specifications,
Espèce(s)
mouse, human, rat

esiRNA

Numéro du produit
Description
Espèce(s)
EHU152861
MISSION® esiRNA, targeting human CYP11B2,
Espèce(s)
human