CDK2AP1
cyclin-dependent kinase 2 associated protein 1
Synonymes:
DOC1, DORC1, ST19, doc-1, p12DOC-1
Espèce(s):
Human CDK2AP1 (8099), Mouse Cdk2ap1 (13445), Rat Cdk2ap1 (360804), domestic cat CDK2AP1 (101089721), domestic guinea pig Cdk2ap1 (100734683), sheep CDK2AP1 (101122554), naked mole-rat Cdk2ap1 (101723683), dog CDK2AP1 (477452), chicken CDK2AP1 (416826), cow CDK2AP1 (615387)
ID UniProtKB:
ID du gène:
- Human(8099) Summary: The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
- Mouse(13445) CDK2 (cyclin-dependent kinase 2)-associated protein 1
- Rat(360804) cyclin-dependent kinase 2 associated protein 1
- domestic cat(101089721) cyclin-dependent kinase 2 associated protein 1
- domestic guinea pig(100734683) cyclin-dependent kinase 2 associated protein 1
- sheep(101122554) cyclin-dependent kinase 2 associated protein 1
- naked mole-rat(101723683) cyclin-dependent kinase 2 associated protein 1
- dog(477452) cyclin-dependent kinase 2 associated protein 1
- chicken(416826) cyclin-dependent kinase 2 associated protein 1
- cow(615387) cyclin-dependent kinase 2 associated protein 1
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-cdk2 Antibody, Upstate®, from rabbit,
Espèces réactives
human
Application
immunoprecipitation (IP)
western blot
western blot
Anti-CDK2AP1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
western blot
Anti-CDK2AP1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
Anti-CDK2AP1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
esiRNA
Référence du produit
Description
Espèce(s)