CASC5
cancer susceptibility candidate 5
Synonymes:
AF15Q14, CT29, D40, KNL1, PPP1R55, Spc7, hKNL-1, hSpc105
Espèce(s):
Human CASC5 (57082), Mouse Casc5 (76464), Rat Casc5 (311327), Zebrafish casc5 (327226), domestic guinea pig Casc5 (100730663), chicken CASC5 (423007), Horse CASC5 (100071354), domestic cat CASC5 (101086398), Domestic Rabbit CASC5 (100346129), cow CASC5 (787969) ...Plus
ID UniProtKB:
ID du gène:
- Human(57082) Summary: The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jan 2013]
- Mouse(76464) cancer susceptibility candidate 5
- Rat(311327) cancer susceptibility candidate 5
- Zebrafish(327226) cancer susceptibility candidate 5
- domestic guinea pig(100730663) cancer susceptibility candidate 5
- chicken(423007) cancer susceptibility candidate 5
- Horse(100071354) cancer susceptibility candidate 5
- domestic cat(101086398) cancer susceptibility candidate 5
- Domestic Rabbit(100346129) cancer susceptibility candidate 5
- cow(787969) cancer susceptibility candidate 5
- dog(478260) cancer susceptibility candidate 5
- sheep(101114616) cancer susceptibility candidate 5
- naked mole-rat(101715049) cancer susceptibility candidate 5
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-KNL1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
Anti-KNL1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-CASC5 antibody produced in rabbit, ,
Espèces réactives
human, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot