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Merck

CACNA1D

calcium channel, voltage-dependent, L type, alpha 1D subunit

Synonymes:
CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, SANDD
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(776) Summary: Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
  • Mouse(12289) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • Rat(29716) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • sheep(101106371) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • domestic cat(101088394) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • Domestic Rabbit(100327259) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • chicken(395895) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • Horse(100051186) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • dog(484724) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • domestic guinea pig(100726255) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • cow(408013) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • naked mole-rat(101714832) calcium channel, voltage-dependent, L type, alpha 1D subunit

Custom & Knockdown Gene Products

Small Molecule - Allosteric Modulator

Numéro du produit
Description
Espèce(s)
Gabapentin, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Gabapentin, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human
Gabapentin solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
Pregabalin, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human
Gabapentin solution, 10 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human

Small Molecule - Antagonist

Numéro du produit
Description
Espèce(s)
Nimodipine, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human
Nimodipine, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Cinnarizine, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human
Felodipine, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Felodipine, British Pharmacopoeia (BP) Reference Standard,
Espèce(s)
human

Antibodies

Numéro du produit
Description
Espèces réactives
Application
Anti-CACNA1D antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Monoclonal Anti-CACNA1D antibody produced in mouse, clone S48A-9, 1 mg/mL, purified immunoglobulin,
Espèces réactives
human, mouse, rat
Application
immunocytochemistry
immunoprecipitation (IP)

western blot
Anti-Calcium Channel (α1D Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Espèces réactives
mouse, rat
Application
immunocytochemistry
immunoprecipitation (IP)

western blot

Small Molecule - Blocker

Numéro du produit
Description
Espèce(s)
Margatoxin, ,
Espèce(s)
mouse, rat, human
Amlodipine besylate, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human
Amlodipine besylate, ≥98% (HPLC),
Espèce(s)
human
Amlodipine besylate, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Verapamil hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human

esiRNA

Numéro du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human CACNA1D,
Espèce(s)
human