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Merck

CACNA1B

calcium channel, voltage-dependent, N type, alpha 1B subunit

Synonymes:
BIII, CACNL1A5, CACNN, Cav2.2
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(774) Summary: The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
  • Mouse(12287) calcium channel, voltage-dependent, N type, alpha 1B subunit
  • Rat(257648) calcium channel, voltage-dependent, N type, alpha 1B subunit
  • cow(282410) calcium channel, voltage-dependent, N type, alpha 1B subunit
  • chicken(374169) calcium channel, voltage-dependent, N type, alpha 1B subunit
  • dog(480660) calcium channel, voltage-dependent, N type, alpha 1B subunit
  • Domestic Rabbit(100008979) calcium channel, voltage-dependent, N type, alpha 1B subunit
  • naked mole-rat(101697609) calcium channel, voltage-dependent, N type, alpha 1B subunit
  • domestic guinea pig(100735203) calcium channel, voltage-dependent, N type, alpha 1B subunit
  • domestic cat(101087362) calcium channel, voltage-dependent, N type, alpha 1B subunit

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Small Molecule - Allosteric Modulator

Référence du produit
Description
Espèce(s)
Levetiracetam, ≥98% (HPLC),
Espèce(s)
human
Levetiracetam, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human
Levetiracetam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
Levetiracetam, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Levetiracetam, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human

Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-Cav2.2 Antibody, Chemicon®, from rabbit,
Espèces réactives
rat
Application
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-CACNA1B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Anti-CACNA1B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
Anti-Calcium Channel (α1B Subunit) (N-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Espèces réactives
mouse, rat
Application
immunocytochemistry
immunoprecipitation (IP)

western blot

Small Molecule - Blocker

Référence du produit
Description
Espèce(s)
Levetiracetam, ≥98% (HPLC),
Espèce(s)
human
Levetiracetam, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human
Levetiracetam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
Levetiracetam, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Levetiracetam, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting mouse Cacna1b,
Espèce(s)
mouse
MISSION® esiRNA, targeting human CACNA1B,
Espèce(s)
human