AKT1
v-akt murine thymoma viral oncogene homolog 1
Synonymes:
AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
Espèce(s):
Human AKT1 (207), Mouse Akt1 (11651), Rat Akt1 (24185), cow AKT1 (280991), fruit fly Akt1 (41957), chicken AKT1 (395928), Zebrafish akt1 (101910198), Goat AKT1 (100860904), sheep AKT1 (100294652), dog AKT1 (490878) ...Plus
ID UniProtKB:
ID du gène:
- Human(207) Summary: The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
- Mouse(11651) thymoma viral proto-oncogene 1
- Rat(24185) v-akt murine thymoma viral oncogene homolog 1
- cow(280991) v-akt murine thymoma viral oncogene homolog 1
- fruit fly(41957) CG4006 gene product from transcript CG4006-RA
- chicken(395928) v-akt murine thymoma viral oncogene homolog 1
- Zebrafish(101910198) v-akt murine thymoma viral oncogene homolog 1
- Goat(100860904) v-akt murine thymoma viral oncogene homolog 1
- sheep(100294652) v-akt murine thymoma viral oncogene homolog 1
- dog(490878) v-akt murine thymoma viral oncogene homolog 1
- domestic guinea pig(100714724) v-akt murine thymoma viral oncogene homolog 1
- sheep(101104184) v-akt murine thymoma viral oncogene homolog 1
- domestic cat(101087931) v-akt murine thymoma viral oncogene homolog 1
- naked mole-rat(101700695) v-akt murine thymoma viral oncogene homolog 1
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ELISA
Référence du produit
Description
Espèce(s)
Phospho-Akt (pSer473) ELISA Kit, for detection of human, mouse or rat phospho-akt (pSer473) in cell and tissue lysates,
Espèce(s)
human
Phospho-Akt (pSer473) / pan-Akt ELISA Kit, for detection of human, mouse or rat phospho-akt (pSer473) and pan-akt in cell and tissue lysates,
Espèce(s)
human
Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-AKT antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-phospho-AKT1 (pThr308) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Akt/PKB Antibody, PH Domain, clone SKB1, clone SKB1, Upstate®, from mouse,
Espèces réactives
human, mouse, rat
Application
flow cytometry
immunocytochemistry
immunoprecipitation (IP)
western blot
immunocytochemistry
immunoprecipitation (IP)
western blot
Anti-Phospho-akt (ser473) antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM251, purified immunoglobulin,
Espèces réactives
human
Application
immunohistochemistry
western blot
western blot
Anti-Phospho-Akt Ser473 antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
western blot
Small Molecule - Inhibitor
Référence du produit
Description
Espèce(s)
Proteins
Référence du produit
Description
Espèce(s)
Akt1/PKBα Protein, active, 15 µg, Active, recombinant full-length human Akt1, containing N-terminal His6 tag, for use in IP-Kinase Assays & Kinase Assays.,
Espèce(s)
human
Akt1 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥75% (SDS-PAGE),
Espèce(s)
human
AKT1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Espèce(s)
human
SILu™Prot AKT1,RAC-alpha serine/threonine-protein kinase human, recombinant, expressed in HEK 293 cells, SIL MS Protein Standard, 13C- and 15N-labeled,
Espèce(s)
human