Toxicity affects all facets of drug development. A guiding tenet in toxicity studies is to eliminate drug candidates that cause toxicity as early as possible. It is critical to identify biomarkers that are not only organ- or tissue-specific but also sensitive enough to identify damage before it becomes extensive.
microRNAs (miRNAs) fulfill the criteria for an ideal biomarker and show superior sensitivity compared to enzyme-based biomarkers.
Watch this webinar to explore how to overcome sample prep and amplification challenges associated with miRNAs to get accurate ultrasensitive quantification without PCR. See how combining high-sensitivity immunoassays with cutting-edge miRNA detection technology empowers you to detect miRNA in biofluids with better reproducibility and ease of use.
You'll also discover why miR-122 has emerged as a novel biomarker for early detection of liver injury and explore the benefits of using it to evaluate drug safety profiles in the early stages of drug development such as minimizing financial loss due to late-stage drug failure.
In this webinar, you will learn:
- What makes miRNA a suitable biomarker for liver toxicity studies and its role in drug development
- Why immunoassays are a critical tool in organ toxicity studies
- How the latest technology enables early and accurate detection of low-abundant liver toxicity biomarkers.
For Research Use Only. Not For Use In Diagnostic Procedures.
Speakers
Juan Díaz-Mochón
DESTINA
Chief Executive Officer
After earning a Ph.D. in Medicinal Chemistry at the Universidad de Granada, Juan J. Díaz-Mochón was a Postdoctoral Research Associate at the University of Southampton and the University of Edinburgh. He then joined Pfizer-University of Granada-Junta de Andalucia Center for Genomics and Oncological Research. In 2017, he established DESTINA Genomics Ltd., focusing on highly specific nucleic acid detection, and is currently the Executive Director and CEO.
Anitaben Tailor, Ph.D.
Merck
Biology Technical Marketing
Anitaben Tailor brings over 10 years of immunoassay platform experience in the biopharmaceutical industry. After her post-doctoral fellowship, she held faculty positions at Johns Hopkins and NIH; then joined the industry in a global role with Merck's Life Science division. More recently, she focuses on the technical marketing of the Immunoassay portfolio within Pharma and CROs.
Protein biology
- Protein quantitation
Durée:40min
Langue:English
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