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  • Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine's rewarding effects but preserves natural reward processing.

Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine's rewarding effects but preserves natural reward processing.

Science advances (2021-10-21)
Andry Andrianarivelo, Estefani Saint-Jour, Paula Pousinha, Sebastian P Fernandez, Anna Petitbon, Veronique De Smedt-Peyrusse, Nicolas Heck, Vanesa Ortiz, Marie-Charlotte Allichon, Vincent Kappès, Sandrine Betuing, Roman Walle, Ying Zhu, Charlène Joséphine, Alexis-Pierre Bemelmans, Gustavo Turecki, Naguib Mechawar, Jonathan A Javitch, Jocelyne Caboche, Pierre Trifilieff, Jacques Barik, Peter Vanhoutte
PMID34669474
ABSTRACT

[Figure: see text].

MATERIALS
Product Number
Brand
Product Description
MAB5782
Sigma-Aldrich
Anti-NMDAR2B Antibody, NT, ascites fluid, clone 1A8.9B3, Chemicon®
05-432
Sigma-Aldrich
Anti-NR1 Antibody, CT, Upstate®, from mouse
D2944
Sigma-Aldrich
Anti-D1 Dopamine Receptor antibody,Rat monoclonal, clone 1-1-F11 s.E6, purified from hybridoma cell culture
ABN462
Sigma-Aldrich
Anti-Dopamine D2 Receptor Antibody, from rabbit, purified by affinity chromatography