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P3636

Sigma-Aldrich

Pentobarbital

Synonym(s):

5-Ethyl-5-(1-methylbutyl)-2,4,6-trioxohexahydropyrimidine, Nembutal

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About This Item

Empirical Formula (Hill Notation):
C11H18N2O3
CAS Number:
76-74-4
Molecular Weight:
226.27
EC Number:
200-983-8
MDL number:
MFCD00057561
UNSPSC Code:
12352200

drug control

USDEA Schedule II; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada

SMILES string

CCCC(C)C1(CC)C(=O)NC(=O)NC1=O

InChI

1S/C11H18N2O3/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)

InChI key

WEXRUCMBJFQVBZ-UHFFFAOYSA-N

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Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301,H336,H361d

Hazard Classifications

Acute Tox. 3 Oral - Repr. 2 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Pharmacokinetics of drugs may differ between small and large mammals (including humans); therefore, drug testing in animal models must be carefully designed. Sprague-Dawley rats were used in cardiac experiments, during which the lopinavir concentration in serum had to match human
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Journal of neurosurgery. Pediatrics, 12(1), 37-43 (2013-05-07)
Barbiturates are widely used in the management of high intracranial pressure (ICP) caused by diffuse brain swelling. The cardiovascular, renal, and immunological side effects of these drugs limit them to last-line therapy. There are few published data regarding the role
Naoe Okamura et al.
Neuropharmacology, 58(1), 166-172 (2009-07-07)
Neuropeptide S (NPS) and its cognate receptor were reported to mediate anxiolytic-like and arousal effects. NPS receptors are predominantly expressed in the brain, especially in limbic structures, including amygdala, olfactory nucleus, subiculum and retrosplenial cortex. In contrast, the NPS precursor
Christa M Helms et al.
The Journal of pharmacology and experimental therapeutics, 331(1), 142-152 (2009-07-31)
The gamma-aminobutyric acid (GABA)(A) receptors mediating the discriminative stimulus effects of ethanol were studied by comparing the potency of ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazol(1,5-a)benzodiazepine-3-carboxylate (Ro15-4513) and ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazol(1,5-a)-benzodiazepine-3-carboxylate (flumazenil, Ro15-1788) to antagonize ethanol, pentobarbital (PB), and midazolam substitution for ethanol. Ro15-4513 has high affinity
Sarah A Mellion et al.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 14(3), 239-247 (2013-02-09)
To evaluate high-dose barbiturates as a second-tier therapy for pediatric refractory intracranial hypertension complicating severe traumatic brain injury. This is a retrospective cohort study of children with refractory intracranial hypertension treated with high-dose barbiturates. A single center level I pediatric
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