F3679
Anti-Frizzled-7 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-FZD7
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About This Item
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
availability
not available in Japan
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4 μg/mL using human kidney
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... FZD7(8324)
mouse ... Fzd7(14369)
General description
Frizzled homolog protein (FZD) is a seven-pass transmembrane type receptor expressed in various normal tissues such as skeletal muscle, kidney, pancreas, cerebellum and cerebral cortex. In human, ten members (FZD1-FZD10) of Frizzled homolog protein have been identified. FZD7 is expressed throughout normal gastrointestinal tract, from esophagus to rectum. It is highly expressed in the gastric cancer cell line MKN7 and relatively lowers in esophageal cancer cell lines.
Immunogen
synthetic peptide corresponding to the N-terminal extracellular domain of human frizzled-7, conjugated to KLH. The immunizing peptide has 100% homology with the mouse gene.
Application
Anti-Frizzled-7 antibody is suitable for immunostaining of liver tissues to localise FZD7 in T and pT tissues. It is also suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 4μg/mL using human kidney.
Biochem/physiol Actions
FZD7 shows 98.8% nucleotide identity with FzE3 and encodes for WNT receptors with nine amino-acid substitutions. In human primary gastric cancer, high level of FZD7 has been found. Mechanistically, over-expression of Frizzled-7 accelerates the WNT-β-catenin-TCF pathway. Through the activation of the WNT-β-catenin-TCF pathway, FZD7, might play key roles in carcinogenesis.
Physical form
Solution in phosphate buffered saline containing 0.01% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Certificates of Analysis (COA)
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H Kirikoshi et al.
International journal of oncology, 19(1), 111-115 (2001-06-16)
Human Frizzled-7 (FZD7) and human FzE3, showing 98.8% nucleotide identity, encode almost identical WNT receptors with nine amino-acid substitutions. FzE3 is claimed to be expressed specifically in esophageal cancer. We determined the structure of the FZD7 gene and the FZD7
A Bengochea et al.
British journal of cancer, 99(1), 143-150 (2008-06-26)
Dysregulation of growth factors and their receptors is central to human hepatocellular carcinoma (HCC). We previously demonstrated that the Frizzled-7 membrane receptor mediating the Wnt signalling can activate the beta-catenin pathway and promotes malignancy in human hepatitis B virus-related HCCs.
Koji Ueno et al.
International journal of cancer, 132(8), 1731-1740 (2012-07-27)
Wnt signaling pathways play important roles in tumorigenesis and are initiated by binding of Wnt to various receptors including frizzleds (FZDs). FZDs are one of several families of receptors comprised of FZD/LRP/ROR2/RYK in the Wnt signaling pathway. Expression of some
H Kirikoshi et al.
International journal of oncology, 19(4), 767-771 (2001-09-20)
Frizzled (FZD) genes encode seven-transmembrane type WNT receptors, which are implicated in carcinogenesis and embryogenesis. We have previously cloned and characterized FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, and FZD10. Here, we investigated expression profiles of all members of
Sze Chuen Cesar Wong et al.
PloS one, 8(11), e79481-e79481 (2013-11-21)
Frizzled homolog 3 receptor was up-regulated in several gastrointestinal cancers such as esophageal and gastric cancers. Moreover, frizzled homolog 3 has recently reported to be expressed in colorectal adenoma specimens. In the present study, we investigated the clinical significance of
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