B3811

B-9430 trifluoroacetate salt

≥98% (HPLC)

• Synonym(s): D-Arg-Arg-Pro-Hyp-Gly-Igl-Ser-D-Igl-Oic-Arg trifluoroacetate salt, D-Arg-[Hyp³, Igl⁵, D-Igl⁷, Oic⁸]-Bradykinin trifluoroacetate salt
• Empirical Formula (Hill Notation): C₆₄H₉₅N₁₉O₁₃ · xC₂HF₃O₂
• CAS Number: 180981-09-3
• Molecular Weight: 1338.56 (free base basis)
• UNSPSC Code: 12352200

Properties

• Assay: ≥98% (HPLC)
• form: solid
• storage condition: protect from light; under inert gas
• solubility: H₂O: ≥2 mg/mL
• shipped in: wet ice
• storage temp.: −20°C

Description

Amino Acid Sequence

Arg-Arg-Pro-Hyp-Gly-Igl-Ser-Igl-Oic-Arg

Biochem/physiol Actions

B-9430 was developed by Gera at the Stewart laboratory¹ and is a stable, potent, and long lasting Bradykinin (BK) antagonist, a candidate anti-inflammatory drug. B-9430 shows potency at bradykinin B2 (pA₂ = 8.6) and B1 receptors (pA₂ = 7.3). Bradykinin is an important growth factor for small-cell lung cancer (SCLC) and prostate cancer (PC). BK receptors are expressed on almost all lung cancer cell lines and on many PC cells. B-9430 is very resistant to kinases and thus shows a very long action in vivo. This peptide is unique among bradykinin antagonists in that it is active after oral administration.

Stable, potent, and long lasting Bradykinin (BK) antagonist, which shows high BK antagonism on both B-1 and B-2 receptors.

Caution

Product is air and light sensitive. Store in the dark.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable