RASA1
RAS p21 protein activator (GTPase activating protein) 1
Synonyms:
CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP
Species:
Human RASA1 (5921), Mouse Rasa1 (218397), Rat Rasa1 (25676), domestic cat RASA1 (101095151), naked mole-rat Rasa1 (101713771), cow RASA1 (282032), domestic guinea pig Rasa1 (100726441), dog RASA1 (479158), sheep RASA1 (101119216), chicken RASA1 (427327)
UniProtKB ID:
Gene ID:
- Human(5921) Summary: The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012]
- Mouse(218397) RAS p21 protein activator 1
- Rat(25676) RAS p21 protein activator (GTPase activating protein) 1
- domestic cat(101095151) RAS p21 protein activator (GTPase activating protein) 1
- naked mole-rat(101713771) RAS p21 protein activator (GTPase activating protein) 1
- cow(282032) RAS p21 protein activator (GTPase activating protein) 1
- domestic guinea pig(100726441) RAS p21 protein activator (GTPase activating protein) 1
- dog(479158) RAS p21 protein activator (GTPase activating protein) 1
- sheep(101119216) RAS p21 protein activator (GTPase activating protein) 1
- chicken(427327) RAS p21 protein activator (GTPase activating protein) 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-RASA1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
Anti-RASA1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
Anti-RASA1, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
Monoclonal Anti-RASA1, (C-terminal) antibody produced in mouse, clone 1E6, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot