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Merck

NR3C2

nuclear receptor subfamily 3, group C, member 2

Synonyms:
MCR, MLR, MR, NR3C2VIT
Species:
Human NR3C2 (4306), Mouse Nr3c2 (110784), Rat Nr3c2 (25672), sheep NR3C2 (101107046), cow NR3C2 (280861), cow NR3C2 (537614), domestic cat NR3C2 (101081977), Horse NR3C2 (100062570), dog NR3C2 (475461), chicken NR3C2 (374131) ...More
UniProtKB ID:
P08235, B0ZBF5, Q2NKL1, Q96KQ8, Q96KQ9
Gene ID:
  • Human(4306) Summary: This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
  • Mouse(110784) nuclear receptor subfamily 3, group C, member 2
  • Rat(25672) nuclear receptor subfamily 3, group C, member 2
  • sheep(101107046) nuclear receptor subfamily 3, group C, member 2
  • cow(280861) nuclear receptor subfamily 3, group C, member 2
  • cow(537614) nuclear receptor subfamily 3, group C, member 2
  • domestic cat(101081977) nuclear receptor subfamily 3, group C, member 2
  • Horse(100062570) nuclear receptor subfamily 3, group C, member 2
  • dog(475461) nuclear receptor subfamily 3, group C, member 2
  • chicken(374131) nuclear receptor subfamily 3, group C, member 2
  • domestic guinea pig(100735309) nuclear receptor subfamily 3, group C, member 2
  • Zebrafish(562171) nuclear receptor subfamily 3, group C, member 2

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Small Molecule - Agonist

Product Number
Description
Species
D7000
Deoxycorticosterone acetate, ,
Species
human
F0180000
Fludrocortisone acetate, European Pharmacopoeia (EP) Reference Standard,
Species
human
F6127
Fludrocortisone acetate, ≥98%,
Species
human
1174001
Deoxycorticosterone acetate, United States Pharmacopeia (USP) Reference Standard,
Species
human
1273003
Fludrocortisone acetate, United States Pharmacopeia (USP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
S1200000
Spironolactone, European Pharmacopoeia (EP) Reference Standard,
Species
human
C0410000
Canrenone, European Pharmacopoeia (EP) Reference Standard,
Species
human
SML1497
Canrenone, ≥97% (HPLC),
Species
human
1619006
Spironolactone, United States Pharmacopeia (USP) Reference Standard,
Species
human
Y0001705
Eplerenone for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
SAB2104689
Anti-NR3C2, (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
horse, human
Application
western blot
AV45599
Anti-NR3C2 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
human, rabbit
Application
immunohistochemistry
western blot
HPA074979
Anti-NR3C2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
MABS1250
Anti-Mineralocorticoid Receptor Antibody, clone 2D6, clone 2D6, from mouse,
Species Reactivity
rat
Application
immunocytochemistry
immunohistochemistry
western blot

esiRNA

Product Number
Description
Species
EHU088591
MISSION® esiRNA, targeting human NR3C2,
Species
human
EMU201261
MISSION® esiRNA, targeting mouse Nr3c2,
Species
mouse