CCNE1
cyclin E1
Synonyms:
CCNE
Species:
Human CCNE1 (898), Mouse Ccne1 (12447), Rat Ccne1 (25729), naked mole-rat Ccne1 (101711961), Horse CCNE1 (100053882), chicken CCNE1 (426117), Zebrafish ccne1 (30188), dog CCNE1 (484610), cow CCNE1 (533526), domestic cat CCNE1 (101086192) ...More
UniProtKB ID:
Gene ID:
- Human(898) Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq, Jul 2008]
- Mouse(12447) cyclin E1
- Rat(25729) cyclin E1
- naked mole-rat(101711961) cyclin E1
- Horse(100053882) cyclin E1
- chicken(426117) cyclin E1
- Zebrafish(30188) cyclin E1
- dog(484610) cyclin E1
- cow(533526) cyclin E1
- domestic cat(101086192) cyclin E1
- sheep(101107124) cyclin E1
- Domestic Rabbit(100134864) cyclin E1
- domestic guinea pig(100727568) cyclin E1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Cyclin E Antibody, clone 1C7 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Cyclin E Antibody, Upstate®, from rabbit,
Species Reactivity
mouse, rat
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Cyclin E1 antibody, Rabbit monoclonal, clone SP146, recombinant, expressed in proprietary host, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
Anti-phospho-Cyclin E1 (pThr395) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
western blot
Anti-CCNE1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Proteins
Product Number
Description
Species
CyclinE1, GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
Cdk2/Cyclin E Protein, active, 10 µg, Active complex of recombinant full length human Cdk2 containing a C-terminal His6-tag & recombinant full-length human Cyclin E containing an N-terminal GST-tag. For use in Kinase Assays.,
Species
human