Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Cancer letters (2012-10-04)

Himashinie V K Diyabalanage, Michael L Granda, Jacob M Hooker

ABSTRACT

One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in vivo in recent studies for many cancer types and stages. In this review, we discuss the most commonly used combinations of histone deacetylase inhibitors and platinum based drugs in the context of their possible mechanisms, efficiency, efficacy, and related drawbacks in preclinical and clinical studies.

MATERIALS

Product Number

Brand

Product Description

357367

Sigma-Aldrich

Platinum, wire, diam. 0.10 mm, 99.99% trace metals basis

267228

Sigma-Aldrich

Platinum, wire, diam. 0.5 mm, 99.9% trace metals basis

267260

Sigma-Aldrich

Platinum, foil, thickness 0.5 mm, 99.99% trace metals basis

267163

Sigma-Aldrich

Platinum, wire, diam. 0.127 mm, 99.99% trace metals basis

357359

Sigma-Aldrich

Platinum, wire, diam. 0.20 mm, ≥99.99% trace metals basis

267201

Sigma-Aldrich

Platinum, wire, diam. 0.5 mm, 99.99% trace metals basis

685453

Sigma-Aldrich

Platinum, nanopowder, <50 nm particle size (TEM)

327433

Sigma-Aldrich

Platinum, foil, thickness 0.125-0.135 mm, 99.9% trace metals basis

327492

Sigma-Aldrich

Platinum, wire, diam. 1.0 mm, 99.9% trace metals basis

267155

Sigma-Aldrich

Platinum, sponge, ≥99.9% trace metals basis

267171

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.99% trace metals basis

373214

Sigma-Aldrich

Platinum, evaporation slug, diam. × L 0.6 cm × 1.2 cm, 99.99% trace metals basis

349372

Sigma-Aldrich

Platinum, foil, thickness 1.0 mm, 99.99% trace metals basis

349399

Sigma-Aldrich

Platinum, wire, diam. 1.5 mm, ≥99.9% trace metals basis

373265

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, thermocouple grade

349364

Sigma-Aldrich

Platinum, foil, thickness 0.025 mm, 99.99% trace metals basis

204013

Sigma-Aldrich

Platinum, powder, 99.995% trace metals basis

298107

Sigma-Aldrich

Platinum, gauze, 52 mesh, 99.9% trace metals basis

303798

Sigma-Aldrich

Platinum, foil, thickness 0.05 mm, ≥99.9% trace metals basis

204048

Sigma-Aldrich

Platinum, powder (coarse), 99.99% trace metals basis

349356

Sigma-Aldrich

Platinum, foil, thickness 0.05 mm, 99.99% trace metals basis

GF04973249

Platinum, wire reel, 2m, diameter 0.063mm, hard, 99.9%

GF13257222

Platinum, foil, 15mm disks, thickness 0.0125mm, as rolled, 99.95%

GF00602266

Platinum, foil, not light tested, 25x25mm, thickness 0.0015mm, as rolled, 99.95%

GF94151257

Platinum, wire reel, 0.5m, diameter 0.25mm, as drawn, 99.998%

GF94947328

Platinum, wire reel, 20m, diameter 0.04mm, annealed, may be used as one component of a thermocouple, 99.99%

GF12094365

Platinum, wire reel, 1m, diameter 0.005mm, wollaston, 99.9%

GF95785060

Platinum, wire reel, 1m, diameter 0.05mm, hard, 99.99%

GF99967561

Platinum, wire reel, 2m, diameter 0.05mm, annealed, may be used as one component of a thermocouple, 99.99%

GF38122893

Platinum, foil, not light tested, 100x100mm, thickness 0.004mm, as rolled, 99.95%