- Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.
Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.
Cancer letters (2012-10-04)
Himashinie V K Diyabalanage, Michael L Granda, Jacob M Hooker
PMID23032720
ABSTRACT
One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in vivo in recent studies for many cancer types and stages. In this review, we discuss the most commonly used combinations of histone deacetylase inhibitors and platinum based drugs in the context of their possible mechanisms, efficiency, efficacy, and related drawbacks in preclinical and clinical studies.
MATERIALS
Product Number
Brand
Product Description
Platinum, foil, not light tested, 25x25mm, thickness 0.0125mm, as rolled, 99.95%
Platinum, wire reel, 0.2m, diameter 0.25mm, as drawn, 99.99+%
Platinum, foil, 0.5m coil, thickness 0.025mm, coil width 1.6mm, as rolled, 99.95%
Platinum, wire reel, 0.2m, diameter 0.001mm, wollaston, 99.9%
Platinum, wire reel, 0.5m, diameter 0.40mm, as drawn, 99.99%
Platinum, foil, not light tested, 25x25mm, thickness 0.001mm, as rolled, 99.95%
Platinum, wire reel, 0.5m, diameter 0.05mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, wire reel, 0.5m, diameter 0.005mm, wollaston, 99.9%
Platinum, foil, 0.5m coil, thickness 0.025mm, coil width 1.2mm, as rolled, 99.95%
Platinum, wire reel, 0.2m, diameter 0.1mm, hard, 99.99%
Platinum, foil, 6mm disks, thickness 0.125mm, as rolled, 99.95%
Platinum, foil, 0.5m coil, thickness 0.025mm, coil width 2mm, as rolled, 99.95%
Platinum, wire reel, 0.2m, diameter 0.8mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, wire reel, 0.2m, diameter 0.002mm, wollaston, 99.9%
Platinum, foil, 4mm disks, thickness 0.1mm, as rolled, 99.99+%
Platinum, wire reel, 0.5m, diameter 0.6mm, as drawn, 99.99+%
Platinum, foil, 15mm disks, thickness 0.1mm, as rolled, 99.99+%
Platinum, foil, 25mm disks, thickness 0.0075mm, as rolled, 99.95%
Platinum, foil, 6mm disks, thickness 0.125mm, as rolled, 99.99+%
Platinum, foil, not light tested, 50x50mm, thickness 0.0005mm, permanent polyester support, 99.85%
Platinum, wire reel, 0.5m, diameter 0.20mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, wire reel, 0.2m, diameter 1.0mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, foil, 0.1m coil, thickness 0.2mm, coil width 5mm, as rolled, 99.95%
Platinum, foil, 10mm disks, thickness 0.025mm, as rolled, 99.95%
Platinum, wire reel, 0.2m, diameter 0.005mm, wollaston, 99.9%
Platinum, wire reel, 0.5m, diameter 0.25mm, hard, 99.95%
Platinum, wire reel, 2m, diameter 0.25mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, foil, not light tested, 25x25mm, thickness 0.0025mm, as rolled, 99.95%
Platinum, wire reel, 20m, diameter 0.025mm, hard, 99.9%
Platinum, wire reel, 0.5m, diameter 0.3mm, as drawn, may be used as one component of a thermocouple, 99.99%