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SML0198

Sigma-Aldrich

Fenoldopam mesylate

≥98% (HPLC)

Synonym(s):

Fenoldopam methanesulfonate

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About This Item

Empirical Formula (Hill Notation):
C16H16ClNO3 · CH4O3S
CAS Number:
67227-57-0
Molecular Weight:
401.86
EC Number:
266-612-7
MDL number:
MFCD04112986
UNSPSC Code:
12352200
PubChem Substance ID:
329825223
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

mp

271 °C (lit.)

solubility

DMSO: ≥15 mg/mL at ~60 °C

storage temp.

room temp

SMILES string

CS(O)(=O)=O.Oc1ccc(cc1)C2CNCCc3c(Cl)c(O)c(O)cc23

InChI

1S/C16H16ClNO3.CH4O3S/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;1-5(2,3)4/h1-4,7,13,18-21H,5-6,8H2;1H3,(H,2,3,4)

InChI key

CVKUMNRCIJMVAR-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812)

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Application

Fenoldopam mesylate may be used to study dopamine D1-mediated cell signaling.

Biochem/physiol Actions

Fenoldopam mesylate (FM) is considered as an effective therapeutic agent to prevent the onset of postoperative AKI (PO-AKI). In healthy cats, FM can stimulate diuresis and be well-tolerated. This benzazepine-derivative is regional specific and does not cause cerebral vasodilation.
Fenoldopam mesylate is a selective dopamine D1 receptor agonist used as an antihypertensive agent. It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D2-like receptors, α1 and α-adrenoceptors, 5HT1 and 5HT2 receptors, or muscarinic receptors. Fenoldopam mesylate causes peripheral vasodilation by stimulating dopamine-1receptors and α2-adrenoceptors, increasing renal blood flow.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H317,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Pharmacokinetics and pharmacodynamics of fenoldopam mesylate for blood pressure control in pediatric patients
Hammer GB, et al.
BMC anesthesiology, 8(1), 6-6 (2008)
The pharmacokinetics of intravenous fenoldopam in healthy, awake cats
O'Neill KE, et al.
Journal of Veterinary Pharmacology and Therapeutics, 39, 202-204 (2016)
51 What is the value of Non-Dialytic therapy in acute kidney injury
Evidence-Based Practice of Critical Care E-book: Expert Consult, 359-359 (2010)
A D Knapton et al.
Methods and findings in experimental and clinical pharmacology, 32(7), 489-497 (2010-11-12)
Exposure of the vasculature to vasodilators, pharmaceuticals and industrial chemicals may lead to injury of the blood vessel wall in animals. Vascular injury may begin with changes in the permeability of vascular endothelial cell and vessels, resulting in possible hemorrhage
Shetal H Padia et al.
Hypertension (Dallas, Tex. : 1979), 59(2), 437-445 (2011-12-29)
Renal dopamine D(1)-like receptors (D(1)Rs) and angiotensin type 2 receptors (AT(2)Rs) are important natriuretic receptors counterbalancing angiotensin type 1 receptor-mediated tubular sodium reabsorption. Here we explore the mechanisms of D(1)R and AT(2)R interactions in natriuresis. In uninephrectomized, sodium-loaded Sprague-Dawley rats
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