C1129

Cholic acid

from bovine and/or ovine, ≥98%

• Synonym(s): 3α,7α,12α-Trihydroxy-5β-cholanic acid, Cholanic acid
• Empirical Formula (Hill Notation): C₂₄H₄₀O₅
• CAS Number: 81-25-4
• Molecular Weight: 408.57
• Beilstein: 2822009
• EC Number: 201-337-8
• MDL number: MFCD00003672
• UNSPSC Code: 12161900
• PubChem Substance ID: 24892356
• NACRES: NA.25

Properties

• biological source: bovine and/or ovine
• description: anionic
• Assay: ≥98%
• form: powder
• mol wt: 408.57 g/mol
• mp: 200-201 °C (lit.)
• functional group: carboxylic acid
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]3([H])C[C@H](O)[C@]4(C)[C@]([H])(CC[C@@]4([H])[C@]3([H])[C@H](O)C2)[C@H](C)CCC(O)=O
• InChI: 1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1
• InChI key: BHQCQFFYRZLCQQ-OELDTZBJSA-N
• Gene Information: human ... CYP1A2(1544)

Description

General description

Cholic acid is a major primary bile acid produced in the liver which facilitates fat absorption and cholesterol excretion. It is a non-denaturing ionic detergent.

Application

Dietary cholic acid has been used in a study to assess its effect on colonic epithelial cell proliferation. It has also been used in a study to investigate extractions and comparisons of human erythrocyte ghosts.

Non-denaturing ionic detergent used for extraction of membrane proteins.

Biochem/physiol Actions

Bile Acid

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves