Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

914460

Sigma-Aldrich

1-Biotinyl-3,6-dioxa-8-octaneamine hydrochloride

≥95%

Synonym(s):

1-Biotinyl-3,6-dioxa-8-octaneamine hydrochloride, N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide hydrochloride, N-{2-[2-(2- Aminoethoxy)ethoxy]ethoxy}biotinamide hydrochloride, Amine-terminated biotin linker, Biotin-DOOA HCl, Biotinylation reagent

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C16H31ClN4O4S
CAS Number:
862373-14-6
Molecular Weight:
410.96
UNSPSC Code:
12352116
NACRES:
NA.22

Quality Level

100

Assay

≥95%

form

powder

storage temp.

2-8°C

Application

1-Biotinyl-3,6-dioxa-8-octaneamine hydrochloride is a versatile biotinylated linker that can be incorporated into chemical tools via its terminal amino group. Labeling materials or proteins with biotin provides a means to enrich and capture targets from biological systems.

Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)

Other Notes

Efficient Innate Immune Killing of Cancer Cells Triggered by Cell Surface Anchoring of Multivalent Antibody-Recruiting Polymers

Caged Cyclopropenes with Improved Tetrazine Ligation Kinetics

A Unified Framework for the Incorporation of Bioorthogonal Compound Exposure Probes within Biological Compartments

A Chemical Probe for Protein Crotonylation

One-Step Selective Exoenzymatic Labeling (SEEL) Strategy for the Biotinylation and Identification of Glycoproteins of Living Cells

related product

Product No.
Description
Pricing

T2879

Tyramine hydrochloride, ≥98%

H1759

(+)-Biotin N-hydroxysuccinimide ester, ≥98% (HPLC), powder

B7639

(+)-Biotin hydrazide, ≥97% (TLC), powder

B5768

Biotin 4-amidobenzoic acid sodium salt, ≥95%

14400

Biotin, ≥99.0% (T)

861650

(+)-Biotin 4-nitrophenyl ester, 98%

B2059

Biotin Polyethyleneoxide Iodoacetamide

764213

Biotin-PEG4-alkyne, for copper catalyzed click labeling

QBD10196

Biotin-dPEG®11-NH2

QBD10826

Biotin-dPEG®7-NH2

SML2135

Biotinyl tyramide, ≥97% (HPLC)

914916

Biotin-SS-tyramide, ≥95%

914134

5-(Biotinamido)pentylamine TFA Salt, ≥95%

914924

3-[2-N-(Biotinyl)aminoethyldithio]propanoic acid, ≥95%

913669

Biotinamidoethyldisulfanyl(2-aminoethane) trifluoroacetic acid

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Annemiek Uvyn et al.
Angewandte Chemie (International ed. in English), 58(37), 12988-12993 (2019-06-18)
Binding of monoclonal antibodies (mAbs) onto a cell surface triggers antibody-mediated effector killing by innate immune cells through complement activation. As an alternative to mAbs, synthetic systems that can recruit endogenous antibodies from the blood stream to a cancer cell
Kosuke Chiba et al.
Chemical communications (Cambridge, England), 53(62), 8751-8754 (2017-07-21)
We herein propose a simple affinity-labeling method using a ligand-4-azidophthalimide (AzPI) conjugate. As a proof of concept, we show that two different ligand-AzPI conjugates enabled highly specific fluorescence labeling of their individual target proteins even in crude cell lysates. This
Benjamin Spangler et al.
ACS infectious diseases, 4(9), 1355-1367 (2018-05-31)
The Gram-negative cell envelope presents a formidable barrier to xenobiotics, and achieving sufficient compound exposure inside the cell is a key challenge for the discovery of new antibiotics. To provide insight on the molecular determinants governing compound exposure in Gram-negative
Wilke C de Vries et al.
ACS applied materials & interfaces, 9(48), 41760-41766 (2017-11-16)
We present the preparation of ligand-conjugated redox-responsive polymer nanocontainers by the supramolecular decoration of cyclodextrin vesicles with a thin redox-cleavable polymer shell that displays molecular recognition units on its surface. Two widely different recognition motifs (mannose-Concanavalin A and biotin-streptavidin) are
Zhiyuan Fang et al.
Chemical communications (Cambridge, England), 49(55), 6164-6166 (2013-06-04)
A direct ELISA was established for the fast detection of semicarbazide (SEM) using a novel biotin derivative. Without a tedious extraction procedure, as low as 0.07 μg L(-1) of SEM could be detected reproducibly. This assay has better recovery and
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service