- A general, practical palladium-catalyzed cyanation of (hetero)aryl chlorides and bromides.
A general, practical palladium-catalyzed cyanation of (hetero)aryl chlorides and bromides.
Angewandte Chemie (International ed. in English) (2013-08-13)
Todd D Senecal, Wei Shu, Stephen L Buchwald
PMID23934947
ABSTRACT
Playing it safe: The nontoxic cyanide source K4 [Fe(CN)6]·3H2O can be used for the cyanation of (hetero)aryl halides. The application of palladacycle catalysts prevents poisoning during catalyst formation, thereby allowing for low catalyst loadings, fast reaction times, and wide heterocyclic substrate scope.
MATERIALS