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Merck

New one-pot synthesis of (E)-beta-aryl vinyl halides from styrenes.

Organic letters (2009-07-04)
Piotr Pawluć, Grzegorz Hreczycho, Justyna Szudkowska, Maciej Kubicki, Bogdan Marciniec
ABSTRACT

A new, efficient protocol for the highly stereoselective one-pot synthesis of (E)-beta-aryl vinyl iodides and (E)-beta-aryl vinyl bromides from styrenes based on sequential ruthenium-catalyzed silylative coupling-N-halosuccinimide-mediated halodesilylation reactions is reported.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Vinyl bromide, 98%
Sigma-Aldrich
Vinyl bromide solution, 1.0 M in THF