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  • Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease.

Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease.

Journal of inorganic biochemistry (2011-11-22)
Maire E Percy, Theo P A Kruck, Aileen I Pogue, Walter J Lukiw
ABSTRACT

In 1991, treatment with low dose intramuscular desferrioxamine (DFO), a trivalent chelator that can remove excessive iron and/or aluminum from the body, was reported to slow the progression of Alzheimer's disease (AD) by a factor of two. Twenty years later this promising trial has not been followed up and why this treatment worked still is not clear. In this critical interdisciplinary review, we provide an overview of the complexities of AD and involvement of metal ions, and revisit the neglected DFO trial. We discuss research done by us and others that is helping to explain involvement of metal ion catalyzed production of reactive oxygen species in the pathogenesis of AD, and emerging strategies for inhibition of metal-ion toxicity. Highlighted are insights to be considered in the quests to prevent potentially toxic effects of aluminum toxicity and prevention and intervention in AD.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Aluminum, sputtering target, diam. × thickness 3.00 in. × 0.125 in., 99.9995% trace metals basis
Sigma-Aldrich
Aluminum, powder, ≥91% (complexometric)
Aluminum, IRMM®, certified reference material, 1.0 mm foil
Sigma-Aldrich
Aluminum, evaporation slug, diam. × L 6.3 mm × 6.3 mm, 99.999% trace metals basis
Sigma-Aldrich
Aluminum, wire, diam. 0.58 mm, ≥99.99% trace metals basis
Sigma-Aldrich
Aluminum, pellets, 3-8 mesh, ≥99.999% trace metals basis
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Aluminum, wire, diam. 1.0 mm, 99.999% trace metals basis
Sigma-Aldrich
Aluminum, granular, <1 mm, 99.7% trace metals basis
Aluminum, IRMM®, certified reference material, 1.0 mm wire
Sigma-Aldrich
Aluminum, foil, thickness 8 μm, 99% trace metals basis
Aluminum, rod, 50mm, diameter 28mm, as drawn, 99.999%
Aluminum, rod, 100mm, diameter 6.0mm, as drawn, 99.999%
Aluminum, microfoil, disks, 50mm, thinness 1.0μm, specific density 269.9μg/cm2, permanent mylar 3.5μm support, 99.999%
Aluminum, tube, 100mm, outside diameter 0.55mm, inside diameter 0.4mm, wall thickness 0.075mm, as drawn, 99.5%
Aluminum, rod, 44mm, diameter 77.5mm, as drawn, 99.999%
Aluminum, tube, 200mm, outside diameter 0.86mm, inside diameter 0.76mm, wall thickness 0.05mm, as drawn, 99.5%
Aluminum, microfoil, disks, 25mm, thinness 0.0075μm, specific density 1.84μg/cm2, permanent mylar 3.5μm support, 99.999%
Aluminum, tube, 0.5m coil, as drawn, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, 99.5%
Aluminum, wire reel, 100m, diameter 0.5mm, as drawn, 99.95+%
Aluminum, wire reel, 100m, diameter 0.063mm, annealed, 99.99%
Aluminum, tube, 100mm, outside diameter 0.6mm, inside diameter 0.3mm, wall thickness 0.15mm, as drawn, 99.5%
Aluminum, mesh, 150x150mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh
Aluminum, tube, 200mm, outside diameter 1.42mm, inside diameter 1.166mm, wall thickness 0.127mm, as drawn, 99.5%
Aluminum, rod, 200mm, diameter 10.0mm, as drawn, 99.999%
Aluminum, tube, 500mm, outside diameter 0.55mm, inside diameter 0.4mm, wall thickness 0.075mm, as drawn, 99.5%
Aluminum, tube, 500mm, outside diameter 3.0mm, inside diameter 1.62mm, wall thickness 0.69mm, hard, 99.5%
Aluminum, wire reel, 100m, diameter 0.25mm, hard, 99.99+%
Aluminum, sphere, 100pcs, diameter 1.0mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%
Aluminum, wire reel, 100m, diameter 0.025mm, as drawn, 99.0+%
Aluminum, rod, 200mm, diameter 12.7mm, 99%