A6428

Aflatoxin M₁

from Aspergillus flavus

• Empirical Formula (Hill Notation): C₁₇H₁₂O₇
• CAS Number: 6795-23-9
• Molecular Weight: 328.27
• EC Number: 229-865-4
• MDL number: MFCD00871812
• UNSPSC Code: 12352200
• PubChem Substance ID: 24891088
• NACRES: NA.77

Properties

• biological source: Aspergillus flavus
• Quality Level: 200
• form: film
• storage temp.: 2-8°C
• SMILES string: [H][C@]12OC=C[C@@]1(O)c3c(O2)cc(OC)c4C5=C(C(=O)CC5)C(=O)Oc34
• InChI: 1S/C17H12O7/c1-21-9-6-10-13(17(20)4-5-22-16(17)23-10)14-12(9)7-2-3-8(18)11(7)15(19)24-14/h4-6,16,20H,2-3H2,1H3/t16-,17-/m1/s1
• InChI key: MJBWDEQAUQTVKK-IAGOWNOFSA-N

Description

General description

Aflatoxins are metabolites of fungus, that are mainly seen in feeds and foods. Aflatoxin M₁ is a hydroxylated metabolite of aflatoxin B₁. It is liberated in milk, urine and produced in liver after receiving aflatoxin B₁.

Application

Aflatoxin M1 has been used as a standard to investigate the incidence and occurrence of aflatoxin M₁ (AFM₁) in Brazilian milk and infant formula. It has also been used as standard to investigate the incidence and occurrence of aflatoxin M1 (AFM₁) in dairy products produced in Brazil.

Aflatoxin M1 is both a hepatotoxic and hepatocarcinogenic mycotoxin that has been shown to cause immunosuppression in animals.

Biochem/physiol Actions

Aflatoxin M1 possesses hepatocarcinogenic properties.

Warning

Possibly carcinogenic.

Preparation Note

Aspergillus flavus metabolite.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H300 + H310 + H330,H340,H350
• Precautionary Statements: P202 - P260 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Carc. 1B - Muta. 1B
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable