A4034

(+)-Sodium L-ascorbate

powder, BioReagent, suitable for cell culture

• Synonym(s): L(+)-Ascorbic acid sodium salt, Vitamin C sodium salt
• Empirical Formula (Hill Notation): C₆H₇NaO₆
• CAS Number: 134-03-2
• Molecular Weight: 198.11
• Beilstein: 3767246
• EC Number: 205-126-1
• MDL number: MFCD00082340
• UNSPSC Code: 12352205
• eCl@ss: 34058010
• PubChem Substance ID: 24890738
• NACRES: NA.75

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• product line: BioReagent
• Assay: ≥98%
• form: powder
• mol wt: M_w 135.13 g/mol
• technique(s): cell culture | mammalian: suitable; cell culture | plant: suitable
• color: white to off-white
• mp: 220 °C (dec.) (lit.)
• solubility: H₂O: 50 mg/mL
• SMILES string: [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-]
• InChI: 1S/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H,1H2;/q;+1/p-1/t2-,5+;/m0./s1
• InChI key: PPASLZSBLFJQEF-RXSVEWSESA-M

Description

General description

(+)-Sodium L-ascorbate (SA) is a potential antioxidant and is a derivative of vitamin C (L-ascorbic acid).[1][2] It is widely used as a food additive.[1] In addition, SA enhances growth retardation activity of bleomycin sulfate, R020-1724 (an inhibitor of cyclic nucleotide phosphodiesterase), prostaglandin E1 and sodium butyrate agents on neuroblastoma cells in culture.[3] Elevated levels of SA induces two-stage urinary bladder carcinogenesis in rats.[1] sodium L-ascorbate in combination with collagenogenesis inhibitors is used to treat dermal scars and keloids.[2]

Application

(+)-Sodium L-ascorbate has been used:

• to produce H₂O₂ in cell culture media[4][5]
• as a reducing agent for a cell-permeable artificial electron donor, N,N,N′,N′-tetramethyl-p-phenylenediamine (TMPD)[6]
• to study its effect on production of collagen and elastic fibers in fibroblasts cultures derived from normal human skin and dermal fat[2]

Used for preparation of plant extracts; reductant for the isolation of chloroplasts.

Biochem/physiol Actions

Antioxidant

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves