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S-010

Supelco

Sildenafil solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C22H30N6O4S
CAS Number:
139755-83-2
Molecular Weight:
474.58
EC Number:
200-659-6
MDL number:
MFCD00867528
UNSPSC Code:
41116107
PubChem Substance ID:
329824411
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

pharmaceutical (small molecule)

format

single component solution

storage temp.

−20°C

SMILES string

O=C1NC(C2=C(OCC)C=CC(S(=O)(N3CCN(C)CC3)=O)=C2)=NC4=C1N(C)N=C4CCC

InChI

1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)

InChI key

BNRNXUUZRGQAQC-UHFFFAOYSA-N

Gene Information

human ... PDE5A(8654)

General description

Sildenafil is a treatment for erectile dysfunction and pulmonary arterial hypertension. Sold under the trade name Viagra®, sildenafil has a history of abuse, including by athletes as a performance enhancing drug. This Certified Spiking Solution® is applicable for use in urine drug testing, sports testing, clinical toxicology or forensic analysis by LC-MS/MS or GC/MS.

Application


  • Effect of topical sildenafil on wound healing and oxidative stress in rats: This study investigates the application of sildenafil in a topical solution form to enhance wound healing and reduce oxidative stress in a rat model, providing insights into its potential therapeutic applications (Tunc and Ercan, 2024).

  • The Physicochemical Compatibility of Sildenafil Injection with Parenteral Medications: Research assesses the compatibility of sildenafil solution when combined with various parenteral medications used in neonatal intensive care, suggesting its safe and effective integration for clinical use (De Silva et al., 2024).

  • Changes in Pulmonary Vascular Resistance and Obstruction Score Following Acute Pulmonary Embolism: This study uses sildenafil in a model of acute pulmonary embolism in pigs to evaluate its effects on pulmonary vascular resistance and obstruction, highlighting its potential in managing this condition (Merit et al., 2024).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Viagra is a registered trademark of Pfizer, Inc.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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[Yesterday, Viagra was a medication].
Jean-Yves Nau
Revue medicale suisse, 9(392), 1396-1397 (2013-07-26)
A A Kamalov et al.
Urologiia (Moscow, Russia : 1999), (3)(3), 29-30 (2013-08-31)
The article presents the results of the study aimed to the evaluation the efficacy of combination therapy with alpha1-blocker (tamsulosin) and phosphodiesterase type 5 inhibitor (sildenafil) in patients with urination disorders and erectile dysfunction (ED). A pilot observational study involving
G Rocha et al.
Minerva pediatrica, 65(3), 271-278 (2013-05-21)
Over the last two decades, new therapies have emerged for the management of congenital diaphragmatic hernia (CDH). The aim of this paper was to review our experience in the management of newborns diagnosed with CDH over a 14-year period. Review
Udomsak Wijitsettakul et al.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 96(6), 683-688 (2013-08-21)
To evaluate the efficacy and safety of Elonza (generic product of sildenafil) 100 mg, a phosphodiesterase type 5 (PDE5) inhibitor, in Thai men with erectile dysfunction (ED). This prospective, Cohort study was conducted for eight weeks. Two hundred ten male
Hamid Mahdiuni et al.
Biophysical chemistry, 175-176, 1-16 (2013-03-19)
Sildenafil was investigated for its interaction with the native and modified human carbonic anhydrase II (hCA II). Modification of exposed histidine side chains with diethyl pyrocarbonate decreased esterase activity of the enzyme. The treatment of both native and modified CA
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