Skip to Content
Merck

Copper-mediated trifluoromethylthiolation of α-diazoesters.

Organic letters (2014-03-26)
Mingyou Hu, Jian Rong, Wenjun Miao, Chuanfa Ni, Yongxin Han, Jinbo Hu
PMID24660960
ABSTRACT

A novel Cu-mediated trifluoromethylthiolation of diazo compounds has been developed that provides a convenient synthetic route for the efficient α-trifluoromethylthiolation of simple esters under mild reaction conditions. The reaction is typically carried out at room temperature, and water could be used to promote the reaction.

MATERIALS
Product Number
Brand
Product Description
1601485
USP
Residual Solvent Class 2 - N,N-Dimethylacetamide, United States Pharmacopeia (USP) Reference Standard
154806
Sigma-Aldrich
N,N-Dimethylacetamide, spectrophotometric grade, ≥99%
D137510
Sigma-Aldrich
N,N-Dimethylacetamide, ReagentPlus®, 99%
38840
Sigma-Aldrich
N,N-Dimethylacetamide, puriss. p.a., ≥99.5% (GC)
17308
Sigma-Aldrich
N,N-Dimethylacetamide, suitable for peptide synthesis, ≥99.8% (GC)
72336
Supelco
N,N-Dimethylacetamide, analytical standard
271012
Sigma-Aldrich
N,N-Dimethylacetamide, anhydrous, 99.8%
185884
Sigma-Aldrich
N,N-Dimethylacetamide, ReagentPlus®, ≥99%
270555
Sigma-Aldrich
N,N-Dimethylacetamide, suitable for HPLC, ≥99.9%