- Peripheral participation of the phosphodiesterase 3 on formalin-evoked nociception.
Peripheral participation of the phosphodiesterase 3 on formalin-evoked nociception.
European journal of pharmacology (2005-08-23)
Jorge E Torres-López, Vinicio Granados-Soto
PMID16111678
ABSTRACT
The local peripheral (subcutaneous) injection of phosphodiesterase 3 inhibitor trequinsin dose-dependently enhanced formalin-evoked flinching during late second phase of this test. Treatment with the nitric oxide synthase inhibitor N-L-nitro-arginine methyl ester or guanylyl cyclase inhibitor 1-H-[1,2,4,]oxadiazolo[4,3-a]quinoxalin-1-one significantly reversed trequinsin-induced pronociceptive effect. Results suggest that the peripheral phosphodiesterase 3 may play an important physiologic role on inflammatory pain by controlling cyclic AMP levels and therefore the nociceptor threshold.
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