- Heteroarylisopropylamines as MAO inhibitors.
Heteroarylisopropylamines as MAO inhibitors.
Bioorganic & medicinal chemistry (2005-05-24)
Gabriel Vallejos, Angélica Fierro, Marcos Caroli Rezende, Silvia Sepúlveda-Boza, Miguel Reyes-Parada
PMID15908219
ABSTRACT
The in vitro monoamine oxidase inhibitory (MAOI) activities of 11 heteroarylisopropylamines vis-à-vis MAO-A and MAO-B were described and interpreted in terms of possible interactions with the enzyme active site. Molecular dynamics simulations allowed a comparison between the most active MAO-A inhibitor of the series, the 1-(2-benzofuryl)-2-aminopropane, and the specific, analogous MAO-A substrate serotonin.