- 1,1-Dibromo-1-alkenes as valuable partners in the copper-catalyzed direct alkynylation of azoles.
1,1-Dibromo-1-alkenes as valuable partners in the copper-catalyzed direct alkynylation of azoles.
Organic letters (2010-08-26)
Beatriz Pacheco Berciano, Sabrina Lebrequier, François Besselièvre, Sandrine Piguel
PMID20735077
ABSTRACT
The copper-catalyzed direct alkynylation of azoles with 1,1-dibromo-1-alkenes as electrophiles is described. These easily accessible substrates are a useful addition to the field of direct alkynylations in an efficient and functional group tolerant reaction to provide a straightforward entry to diverse alkynyl heterocycles.
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