- mRNA pseudouridylation affects RNA metabolism in the parasite
mRNA pseudouridylation affects RNA metabolism in the parasite
RNA (New York, N.Y.) (2017-08-31)
Margaret A Nakamoto, Alexander F Lovejoy, Alicja M Cygan, John C Boothroyd
PMID28851751
ABSTRACT
RNA contains over 100 modified nucleotides that are created post-transcriptionally, among which pseudouridine (Ψ) is one of the most abundant. Although it was one of the first modifications discovered, the biological role of this modification is still not fully understood. Recently, we reported that a pseudouridine synthase (TgPUS1) is necessary for differentiation of the single-celled eukaryotic parasite
MATERIALS