- Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis.
Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis.
Scientific reports (2017-03-30)
Timo Rademakers, Emiel P C van der Vorst, Isabelle T M N Daissormont, Jeroen J T Otten, Kosta Theodorou, Thomas L Theelen, Marion Gijbels, Andrey Anisimov, Harri Nurmi, Jan H N Lindeman, Andreas Schober, Sylvia Heeneman, Kari Alitalo, Erik A L Biessen
PMID28349940
ABSTRACT
During plaque progression, inflammatory cells progressively accumulate in the adventitia, paralleled by an increased presence of leaky vasa vasorum. We here show that next to vasa vasorum, also the adventitial lymphatic capillary bed is expanding during plaque development in humans and mouse models of atherosclerosis. Furthermore, we investigated the role of lymphatics in atherosclerosis progression. Dissection of plaque draining lymph node and lymphatic vessel in atherosclerotic ApoE
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