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  • Antibacterial activity of the soil-bound antimicrobials oxytetracycline and ofloxacin.

Antibacterial activity of the soil-bound antimicrobials oxytetracycline and ofloxacin.

Environmental toxicology and chemistry (2014-01-11)
Feng-Jiao Peng, Li-Jun Zhou, Guang-Guo Ying, You-Sheng Liu, Jian-Liang Zhao
ABSTRACT

Soil contamination of antimicrobials has become an increasing concern because of the potential risks to the soil microbial ecosystem and human health. The present study investigated sorption and desorption behaviors of oxytetracycline (OTC) and ofloxacin (OFL) in 3 typical soils (A, B, and C), and evaluated the antibacterial activity of soil-adsorbed compounds to a pure sensitive strain Escherichia coli ATCC 25922. The results showed different sorption and desorption behaviors of OTC and OFL in the 3 soils, behaviors that were mainly influenced by soil organic matter content and cation exchange capacity (CEC) as well as pH value. In addition, complexation and cation-exchange reactions were shown to be the main sorption mechanisms. Strong adsorption was found in soil B (with a high organic matter content) and in soil C (with high CEC), whereas enhanced desorption was observed in soil A (with low organic matter content). The results also demonstrated that soil-bound antimicrobials retained antibacterial activity toward E. coli. Opposite patterns of antibacterial activity were found for the 2 antimicrobials in the 3 soils: A>B>C for OFL; and C>B>A for OTC. This finding suggests that soil-bound antimicrobials could still exert selective pressure on soil bacteria although less effectively in comparison with the dissolved forms.

MATERIALS
Product Number
Brand
Product Description

Supelco
Oxytetracycline hydrochloride, VETRANAL®, analytical standard
Pricing and availability is not currently available.
Sigma-Aldrich
Oxytetracycline hydrochloride
Pricing and availability is not currently available.
Sigma-Aldrich
Oxytetracycline dihydrate, Assay (anhydrous basis) 95.0%-102.0%
Pricing and availability is not currently available.
Supelco
Oxytetracycline Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
Pricing and availability is not currently available.
USP
Oxytetracycline hydrochloride, United States Pharmacopeia (USP) Reference Standard
Pricing and availability is not currently available.
Oxytetracycline hydrochloride, European Pharmacopoeia (EP) Reference Standard
Pricing and availability is not currently available.
USP
Oxytetracycline, United States Pharmacopeia (USP) Reference Standard
Pricing and availability is not currently available.
Supelco
Ofloxacin, Pharmaceutical Secondary Standard; Certified Reference Material
Pricing and availability is not currently available.
USP
Ofloxacin, United States Pharmacopeia (USP) Reference Standard
Pricing and availability is not currently available.
Ofloxacin, European Pharmacopoeia (EP) Reference Standard
Pricing and availability is not currently available.
Sigma-Aldrich
Ofloxacin, fluoroquinolone antibiotic
Pricing and availability is not currently available.
Millipore
Oxytetra Selective Supplement, suitable for microbiology
Pricing and availability is not currently available.
Supelco
Ofloxacin, VETRANAL®, analytical standard
Pricing and availability is not currently available.