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  • Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro.

Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro.

Phytotherapy research : PTR (2003-05-16)
Ray-Ling Huang, Yu-Ling Huang, Jun-Chih Ou, Chien-Chih Chen, Feng-Lin Hsu, Chungming Chang
ABSTRACT

Using an HBV-producing cell line and inhibition of the expression of the HBsAg and HBeAg as antiviral indicators, a study was conducted on 25 compounds isolated from four Phyllanthus (Euphorbiaceae) plants, including P. amarus Schum. & Thonn., P. multi florus Willd., P. tenellus Roxb. and P. virgatus Forst. f. It was found that niranthin (1), nirtetralin (3), hinokinin (5) and geraniin (13) at the non-cytotoxic concentration of 50 micro m, suppressed effectively both HBsAg and HBeAg expression, with the highest inhibition at 74.3%, 45.3%; 69.6%, 33.9%; 68.1%, 52.3%; 32.1%, 46.6%, respectively. Of these, niranthin (1) showed the best anti-HBsAg activity, while the most potent anti-HBeAg activity was observed with hinokinin (5).

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Nirtetralin, ≥95% (LC/MS-ELSD)