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  • Highly N2-selective coupling of 1,2,3-triazoles with indole and pyrrole.

Highly N2-selective coupling of 1,2,3-triazoles with indole and pyrrole.

Chemistry (Weinheim an der Bergstrasse, Germany) (2014-01-01)
Jian Wen, Li-Li Zhu, Qing-Wei Bi, Zhu-Qing Shen, Xiao-Xiao Li, Xin Li, Zhen Wang, Zili Chen
ABSTRACT

Hydrogen-bond mediated coupling of 1,2,3-triazoles to indoles and pyrroles results in N2 selective functionalization of the triazole moiety in moderate to excellent yields. The reaction was tolerant of un-, mono- and disubstituted triazoles and was applied to synthesize tryptophan derived fluorescent amino acids.

MATERIALS
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Brand
Product Description

Sigma-Aldrich
Pyrrole, reagent grade, 98%