- A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.
Nature (1994-12-22)
J C Lee, J T Laydon, P C McDonnell, T F Gallagher, S Kumar, D Green, D McNulty, M J Blumenthal, J R Heys, S W Landvatter, J E Strickler, M M McLaughlin, I R Siemens, S M Fisher, G P Livi, J R White, J L Adams, P R Young
PMID7997261
ABSTRACT
Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio-photoaffinity-labelled chemical probes, the target of these compounds was identified as a pair of closely related mitogen-activated protein kinase homologues, termed CSBPs. Binding of the pyridinyl-imidazole compounds inhibited CSBP kinase activity and could be directly correlated with their ability to inhibit cytokine production, suggesting that the CSBPs are critical for cytokine production.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
p38/SAPK2 Inhibitor (SB 202190), The p38/SAPK2 Inhibitor (SB 202190) controls the biological activity of p38/SAPK2. This small molecule/inhibitor is primarily used for Biochemicals applications.